DingYuan Bai, YuXuan Zhou, LingJie Jing, Cheng Guo, QuanJun Yang
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引用次数: 0
Abstract
Arginine, a conditionally essential amino acid, orchestrates critical metabolic networks in cancer biology and immunotherapy. Abnormalities in arginine metabolism are associated with cancer initiation, progression and immune escape. Polyamines and nitric oxide are the key metabolites with multiple regulatory effects on cancer cell growth and immune cells by driving metabolic reprogramming and promoting immune evasion in cancer cells. Targeting key enzymes and transporters in arginine pathways, along with arginine deprivation therapy, shows promise in preclinical and clinical studies. This review summarizes the regulatory mechanisms of arginine metabolism and evaluates its potential as a therapeutic target in cancer therapy. We specifically discuss the multifaceted roles of arginine and its metabolites in cancer progression, immune cell regulation, and immunotherapy, providing a theoretical foundation for its application in cancer prevention and treatment.
期刊介绍：
Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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