Estimating the national seroprevalence of Toxoplasma gondii infection in pregnant women, France 2021.

IF 2.2 4区 医学 Q3 INFECTIOUS DISEASES
Sara Mazzilli, Mathieu Tourdjman, Harold Noël, Anna Maisa, Isabelle Villena, Camille Le-Ray
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引用次数: 0

Abstract

Toxoplasmosis during pregnancy can cause congenital malformations and fetal death. This study aimed to estimate the Toxoplasma gondii seroprevalence among pregnant women participating in the 2021 French national perinatal survey and identify associated factors. All women giving birth in France during the study period were invited to participate. Data collected included demographic information, nationality, socio-economic status, education level, and Toxoplasma gondii serological status. Women were classified as seropositive if IgG antibodies were present or if seroconversion occurred during pregnancy. Univariate and multivariate Poisson regression analyses with robust error variance were used to estimate prevalence ratios and identify factors associated with seropositivity. Among 12,612 women, the overall seroprevalence was 25.9%, and 0.22% seroconverted during pregnancy. Seroprevalence increased by 5% with every 5-year age increment and was significantly higher in the French overseas territories of Mayotte (75.0%), La Réunion (35.8%), and French Guiana (33.3%). Seroprevalence was also higher among women with lower educational levels (47.4% for primary education) and those of Sub-Saharan African nationality (52.0%). Geographic and socio-demographic variations may reflect dietary and environmental diversity. Despite declining seroprevalence in France, continued public health efforts, particularly among high-risk populations, remain critical to minimize the impact of congenital toxoplasmosis.

估计法国孕妇弓形虫感染的全国血清阳性率,2021年。
妊娠期弓形虫病可导致先天性畸形和胎儿死亡。本研究旨在估计参加2021年法国全国围产期调查的孕妇中刚地弓形虫的血清患病率,并确定相关因素。所有在研究期间在法国分娩的妇女都被邀请参加。收集的数据包括人口统计信息、国籍、社会经济状况、教育程度和刚地弓形虫血清学状况。如果IgG抗体存在或在怀孕期间发生血清转换,则将妇女归类为血清阳性。单变量和多变量泊松回归分析采用稳健误差方差来估计患病率和确定与血清阳性相关的因素。在12612名妇女中,总血清阳性率为25.9%,妊娠期间血清转化率为0.22%。血清阳性率每增加5岁增加5%,在法国海外领地马约特岛(75.0%)、拉马苏尼亚(35.8%)和法属圭亚那(33.3%)明显较高。受教育程度较低的妇女(初等教育程度为47.4%)和撒哈拉以南非洲国籍妇女(52.0%)的血清患病率也较高。地理和社会人口的差异可能反映了饮食和环境的多样性。尽管法国的血清患病率有所下降,但持续的公共卫生努力,特别是在高危人群中,对于尽量减少先天性弓形虫病的影响仍然至关重要。
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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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