Obstructive sleep apnea and the gut microbiota - mechanisms and opportunities.

IF 2.8 3区医学 Q2 RESPIRATORY SYSTEM

Current Opinion in Pulmonary Medicine Pub Date : 2025-11-01 Epub Date: 2025-09-03 DOI:10.1097/MCP.0000000000001211

Joe Alcock

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引用次数: 0

Abstract

Purpose of review: The relationship between obstructive sleep apnea (OSA) and the gut microbiota is increasingly recognized, yet the involvement of specific microbial taxa and the direction of causality remain unclear. This review synthesizes current evidence linking gut dysbiosis with disordered sleep, with a focus on OSA and its associated complications.

Recent findings: Studies of alpha and beta microbial diversity in OSA patients, sampled at different sites, have had inconsistent results. Members of the genus Fusobacterium and family Lachnospiraceae are enriched in some studies of OSA and have been linked with gut barrier permeability and complications, such as hypertension. OSA treatments, including positive airway pressure and GLP-1 agonists, have varying effects on the microbiota.

Summary: Microbiota-targeted therapies may reduce OSA-related complications, but these potential treatments require additional well designed trials to clarify the bidirectional relationship between gut microbes and sleep-related health.

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阻塞性睡眠呼吸暂停和肠道微生物群-机制和机会。

综述目的：阻塞性睡眠呼吸暂停（OSA）与肠道微生物群之间的关系越来越被人们所认识，但具体的微生物类群的参与和因果关系的方向仍不清楚。本综述综合了目前肠道生态失调与睡眠障碍相关的证据，重点关注了OSA及其相关并发症。最近的发现：对OSA患者的α和β微生物多样性的研究，在不同的地点取样，结果不一致。在OSA的一些研究中，Fusobacterium属和Lachnospiraceae科的成员丰富，并且与肠道屏障通透性和并发症（如高血压）有关。OSA治疗，包括气道正压和GLP-1激动剂，对微生物群有不同的影响。总结：微生物群靶向治疗可能会减少osa相关并发症，但这些潜在的治疗方法需要额外设计良好的试验来阐明肠道微生物与睡眠相关健康之间的双向关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Pulmonary Medicine 医学-呼吸系统

CiteScore

6.20

自引率

0.00%

发文量

109

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Pulmonary Medicine is a highly regarded journal offering insightful editorials and on-the-mark invited reviews, covering key subjects such as asthma; cystic fibrosis; infectious diseases; diseases of the pleura; and sleep and respiratory neurobiology. Published bimonthly, each issue of Current Opinion in Pulmonary Medicine introduces world renowned guest editors and internationally recognized academics within the pulmonary field, delivering a widespread selection of expert assessments on the latest developments from the most recent literature.