Inside Back Cover: Flexibility-Aided Orientational Self-Sorting and Transformations of Bioactive Homochiral Cuboctahedron Pd12L16 (Angew. Chem. 37/2025)

Abstract

With great respect for bears, which, in the past, were used to harvest their bile containing ursodeoxycholic acid – a key building block in this study – we developed a flexible and unsymmetric coordination ligand L. L reacts with salts of shiny palladium forming helical Pd₆L₈ and Pd₁₂L₁₆ cages via flexibility-aided orientational self-sorting. The cages undergo structural transformations induced by changing reaction conditions and exhibit toxicity in vitro using spheroids of hepatic cells HepG2. Details of the study are reported by Ondřej Jurček et al. in their Research Article (e202513902).