Two-Stage Treatment for Adult Large Patent Ductus Venosus

IF 3.3 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Shohei Kudo, Shiro Onozawa, Ryosuke Miyauchi, Ryota Matsuki, Yoshihiro Sakamoto
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引用次数: 0

Abstract

Patent ductus venosus is a congenital portosystemic shunt that may cause progressive portal hypertension, hepatic encephalopathy, and focal nodular hyperplasia of the liver. Embolization of the Arantius' duct is the first choice of treatment in infants and children. However, it carries the risk of coil migration into the systemic circulation in adult patients with larger Arantius ducts. Additionally, the primary closure of the Arantius' duct may result in acute portal hypertension. Herein, we present a two-stage treatment for adult patent large ductus venosus (Arantius' duct). A 23-year-old female patient with hypoalbuminemia showed a patent large Arantius' duct (diameter = 45 mm), intrahepatic portal venous hypoplasia, and multiple hepatic nodules with dynamic computed tomography (CT). Preoperative angiography showed the absence of the intrahepatic portal vein, and tentative occlusion of the Arantius' duct increased the portal pressure from 9 to 15 mmHg with visualization of only a few portal branches. Therefore, we conducted a two-stage treatment for the Arantius' duct. In the first stage, we used an open approach to perform angioplasty of the Arantius' duct to reduce the size from 45 to 8 mm in diameter, which gradually increased the intrahepatic portal blood flow in the follow-up CT scan. The second-stage embolization of the Arantius' duct was performed using an interventional procedure via the internal jugular vein 4 months after the first stage. The patient's recovery was uneventful, and post-treatment CT showed increased intrahepatic portal flow. Serum albumin value increased from 2.7 to 3.7 g/dL 2 weeks post-treatment.

Abstract Image

成人大静脉导管未闭的两阶段治疗
静脉导管未闭是一种先天性门静脉系统分流,可导致进行性门静脉高压症、肝性脑病和肝局灶性结节性增生。阿兰提斯导管栓塞是婴儿和儿童的首选治疗方法。然而,对于有较大阿兰蒂乌斯导管的成年患者,它有线圈迁移到体循环的风险。此外,阿兰蒂乌斯导管的原发性关闭可能导致急性门静脉高压。在此,我们提出成人大静脉导管未闭的两阶段治疗。23岁女性低白蛋白血症患者,动态CT表现为大阿兰蒂斯管未闭(直径45mm),肝内门静脉发育不全,多发肝结节。术前血管造影显示肝内门静脉缺失,Arantius导管的暂时性阻塞使门静脉压力从9增加到15 mmHg,仅可见少量门静脉分支。因此,我们对阿兰提斯导管进行了两阶段治疗。在第一阶段,我们采用开放入路对Arantius管进行血管成形术,将直径从45 mm缩小到8 mm,在后续CT扫描中逐渐增加肝内门静脉血流。第一期术后4个月,采用颈内静脉介入手术对Arantius导管进行第二期栓塞。患者恢复顺利,治疗后CT显示肝内门静脉血流增加。治疗后2周,血清白蛋白由2.7 g/dL升高至3.7 g/dL。
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来源期刊
Annals of Gastroenterological Surgery
Annals of Gastroenterological Surgery GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.30
自引率
11.10%
发文量
98
审稿时长
11 weeks
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