Boston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer's disease and related dementias

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-09 DOI:10.1002/alz.70654

Michael L. Alosco, Madeline Morrison, Rhoda Au, Eric G. Steinberg, Jane Mwicigi, Monica Ly, Caroline Altaras, Steve Lenio, Myriam Abdennadher, Maureen K. O'Connor, Yorghos Tripodis, Joseph Palmisano, Diane Dixon, Brett Martin, Greta Schneider, Jenna R. Groh, Andrew Ellison, Dean Sheppard, Chad W. Farris, Christopher Nowinski, Robert C. Cantu, Katherine W. Turk, Lindsay Farrer, Gyungah Jun, Lee E. Goldstein, Wei Qiao Qiu, Thor D. Stein, Andrew E. Budson, Ann C. McKee, Jesse Mez

{"title":"Boston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer's disease and related dementias","authors":"Michael L. Alosco, Madeline Morrison, Rhoda Au, Eric G. Steinberg, Jane Mwicigi, Monica Ly, Caroline Altaras, Steve Lenio, Myriam Abdennadher, Maureen K. O'Connor, Yorghos Tripodis, Joseph Palmisano, Diane Dixon, Brett Martin, Greta Schneider, Jenna R. Groh, Andrew Ellison, Dean Sheppard, Chad W. Farris, Christopher Nowinski, Robert C. Cantu, Katherine W. Turk, Lindsay Farrer, Gyungah Jun, Lee E. Goldstein, Wei Qiao Qiu, Thor D. Stein, Andrew E. Budson, Ann C. McKee, Jesse Mez","doi":"10.1002/alz.70654","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p>We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post-traumatic Alzheimer's disease (AD) and AD-related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and/or tau positron emission tomography (PET) on a subset. As of 3/2025, the CC consists of 467 participants (mean age: 65.6, 50.1% female), including 163 RHI and 302 TBI who completed a UDS 3.0 baseline visit. Common sources of RHI included football (<i>n</i> = 95), soccer (<i>n</i> = 26), ice hockey (<i>n</i> = 17), and military service (<i>n</i> = 46). Most TBIs were mild (97.7%). Eighty-nine percent agreed to brain donation. The BU ADRC CC will facilitate research, education, and training on post-traumatic AD/ADRD.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>The Boston University Alzheimer's Disease Research Center (ADRC) Clinical Core facilitates unique research, education, and training on Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) with a focus on post-traumatic AD/ADRD, including chronic traumatic encephalopathy (CTE).</li>\n \n <li>We summarize the rationale, mission, study design, and recent updates for the Clinical Core.</li>\n \n <li>As of March 2025, the Clinical Core includes a longitudinal cohort of 467 participants enriched for repetitive head impacts (∼1/3) and traumatic brain injury (∼1/3) exposure who span the cognitive continuum, with most having available fluid and neuroimaging biomarker data and agreeing to brain donation (89%).</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 9","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70654","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70654","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post-traumatic Alzheimer's disease (AD) and AD-related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and/or tau positron emission tomography (PET) on a subset. As of 3/2025, the CC consists of 467 participants (mean age: 65.6, 50.1% female), including 163 RHI and 302 TBI who completed a UDS 3.0 baseline visit. Common sources of RHI included football (n = 95), soccer (n = 26), ice hockey (n = 17), and military service (n = 46). Most TBIs were mild (97.7%). Eighty-nine percent agreed to brain donation. The BU ADRC CC will facilitate research, education, and training on post-traumatic AD/ADRD.

Highlights

The Boston University Alzheimer's Disease Research Center (ADRC) Clinical Core facilitates unique research, education, and training on Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) with a focus on post-traumatic AD/ADRD, including chronic traumatic encephalopathy (CTE).
We summarize the rationale, mission, study design, and recent updates for the Clinical Core.
As of March 2025, the Clinical Core includes a longitudinal cohort of 467 participants enriched for repetitive head impacts (∼1/3) and traumatic brain injury (∼1/3) exposure who span the cognitive continuum, with most having available fluid and neuroimaging biomarker data and agreeing to brain donation (89%).

Abstract Image

查看原文本刊更多论文

波士顿大学阿尔茨海默病研究中心临床核心：促进创伤后阿尔茨海默病和相关痴呆研究的基础设施

我们描述了波士顿大学阿尔茨海默病研究中心（BU ADRC）临床核心（CC）的基本原理、方法和设计。CC对有/无脑外伤的参与者进行纵向队列研究，以表征创伤后阿尔茨海默病（AD）和AD相关痴呆（ADRD）的临床表现、生物标志物特征和危险因素，包括慢性创伤性脑病（CTE）。参与者完成创伤性脑损伤（TBI）和重复性头部撞击（RHIs）的评估；年度统一数据集（UDS）和补充评估；数字表型出现;每年抽血；每3年进行一次磁共振成像和腰椎穿刺检查；脑电图(EEG);以及淀粉样蛋白和/或tau正电子发射断层扫描（PET）。截至2025年3月，CC包括467名参与者（平均年龄：65.6岁，女性50.1%），其中163名RHI和302名TBI完成了UDS 3.0基线访问。RHI的常见来源包括足球（n = 95）、足球（n = 26）、冰球（n = 17）和兵役（n = 46）。大多数tbi是轻度的（97.7%）。89%的人同意捐献大脑。创伤后AD/ADRD中心将促进创伤后AD/ADRD的研究、教育和培训。波士顿大学阿尔茨海默病研究中心（ADRC）临床核心促进了阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）的独特研究、教育和培训，重点是创伤后AD/ADRD，包括慢性创伤性脑病（CTE）。我们总结了临床核心的基本原理、使命、研究设计和最近的更新。截至2025年3月，临床核心包括467名参与者的纵向队列，这些参与者具有重复性头部撞击（~ 1/3）和创伤性脑损伤（~ 1/3）暴露，他们跨越认知连续体，大多数具有可用的液体和神经成像生物标志物数据，并同意脑捐赠（89%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.