{"title":"Second-line strategies more effective than dose optimization in depression treatment","authors":"","doi":"10.1002/pu.31358","DOIUrl":null,"url":null,"abstract":"<p>Alternative second-line treatments for major depressive disorder led to higher response and remission rates in comparison to commonly used dose optimization in a randomized trial. The combination of a selective serotonin reuptake inhibitor (SSRI) and psychotherapy resulted in the lowest prevalence of adverse events among the studied second-line strategies.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 10","pages":"3-4"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Brown University Psychopharmacology Update","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pu.31358","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Alternative second-line treatments for major depressive disorder led to higher response and remission rates in comparison to commonly used dose optimization in a randomized trial. The combination of a selective serotonin reuptake inhibitor (SSRI) and psychotherapy resulted in the lowest prevalence of adverse events among the studied second-line strategies.
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