A history of gastrectomy is a risk factor for choledocholithiasis in patients undergoing cholecystectomy: A single center retrospective study

IF 3.3 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Yuki Matsui, Daisuke Hashimoto, So Yamaki, Kazuki Matsumura, Hidetaka Miyazaki, Yuji Ikeda, Denys Tsybulskyi, Thanh Sang Nguyen, Sohei Satoi
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Abstract

Aim

The incidence of cholelithiasis after gastrectomy is higher than that in the general population; however, the incidence and risk factors for choledocholithiasis have not been well reported. We aimed to assess the association between a history of gastrectomy and choledocholithiasis.

Methods

A total of 3025 patients who underwent cholecystectomy with or without choledocholithotomy between January 2006 and December 2020 at Kansai Medical University, Japan were included in this study. Patients were divided into a gastrectomy group with a history of gastrectomy (173 patients, 5.7%) and a control group having no history of gastrectomy (2852 patients, 94.3%).

Results

The incidence of choledocholithiasis was 61.8% and 22.2% in the gastrectomy and control groups, respectively, with a significantly higher incidence in the gastrectomy group (p < 0.0001). Multivariate analysis showed that age, sex, history of gastrectomy, and previous surgery except gastrectomy were risk factors for the development of choledocholithiasis, with a history of gastrectomy being the strongest risk factor (Odds Ratio 3.78, 95% Confidence Interval 2.71–5.27). The incidence values of choledocholithiasis in the Billroth I, Billroth II, and Roux-en-Y methods were 44.7%, 70.6%, and 69.7%, respectively, and were significantly lower in the Billroth I group than in the Roux-en-Y group (p = 0.009). The median time from gastrectomy to development of choledocholithiasis was 5.5 years for Roux-en-Y, which was significantly faster than 20 years for Billroth I and 35 years for Billroth II.

Conclusion

Gastrectomy is a known risk factor for choledocholithiasis. Concomitant cholecystectomy during gastrectomy may be indicated in older men.

Abstract Image

胃切除术史是胆囊切除术患者胆总管结石的危险因素:一项单中心回顾性研究
目的胃切除术后胆石症的发生率高于普通人群;然而,胆总管结石的发病率和危险因素尚未得到很好的报道。我们的目的是评估胃切除术史和胆总管结石之间的关系。方法选取2006年1月至2020年12月在日本关西医科大学行胆囊切除术或不行胆总管取石术的3025例患者为研究对象。患者分为有胃切除术史的胃切除术组(173例,5.7%)和无胃切除术史的对照组(2852例,94.3%)。结果胃切除术组和对照组胆总管结石发生率分别为61.8%和22.2%,其中胃切除术组发生率显著高于对照组(p < 0.0001)。多因素分析显示,年龄、性别、胃切除术史、除胃切除术外的其他手术是胆总管结石发生的危险因素,其中胃切除术史是最强的危险因素(优势比3.78,95%可信区间2.71 ~ 5.27)。Billrothⅰ组、Billrothⅱ组和Roux-en-Y组胆总管结石的发生率分别为44.7%、70.6%和69.7%,且Billrothⅰ组显著低于Roux-en-Y组(p = 0.009)。Roux-en-Y组从胃切除术到发生胆总管结石的中位时间为5.5年,明显快于Billroth I组20年和Billroth II组35年。结论胃切除术是胆总管结石的危险因素。老年男性在胃切除术时可同时行胆囊切除术。
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来源期刊
Annals of Gastroenterological Surgery
Annals of Gastroenterological Surgery GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.30
自引率
11.10%
发文量
98
审稿时长
11 weeks
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