Maryam Ashourpour, Jamal Mohammadian, Amir Mehdizadeh, Mina Afrashteh Nour, Amir Ghorbanihaghjo
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引用次数: 0
Abstract
Cancer is one of the major public health challenges worldwide, and the STAT3 signaling pathway is recognized as one of the most important signaling pathways in the progression of this disease. This pathway can increase the survival and proliferation of cancer cells and their resistance to treatment by regulating lipid and carbohydrate metabolism, apoptosis, and inflammatory processes. Therefore, STAT3 inhibition is considered an effective therapeutic approach in the fight against cancer. Two main strategies (direct and indirect) have been considered to inhibit this protein, with direct inhibition being more effective due to its more specific properties. Extensive research is also underway to design and develop effective inhibitors for STAT3, and in this regard, SH2 domain inhibitors have reached clinical trial phases.
期刊介绍：
BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease.
The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements.
In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
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