Impact of Childhood Neighborhood Deprivation on White Matter and Functional Connectivity During Adolescence

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2025-09-07 DOI:10.1111/jon.70087

Hector Acosta-Rodriguez, Pratheek Bobba, Alicia Stephan, Tal Zeevi, Ajay Malhotra, Anh Tuan Tran, Simone Kaltenhauser, Laura Ment, Seyedmehdi Payabvash

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引用次数: 0

Abstract

Background and Purpose

Socioeconomic determinants of health impact childhood development and adult health outcomes. One key aspect is the physical environment and neighborhood where children live and grow. Emerging evidence suggests that neighborhood deprivation, often measured by the Area Deprivation Index (ADI), may influence neurodevelopment, but longitudinal and multimodal neuroimaging analyses remain limited.

Methods

We examined the association between childhood neighborhoods and brain white matter (WM) microstructural integrity using a large, demographically representative cohort from the Adolescent Brain Cognitive Development Study. We analyzed the relationship between ADI and MRI metrics of WM microstructural integrity and resting-state funtional magnetic resonance imaging (rs-fMRI) connectivity in children with data at baseline (mean age of 9.9 years) and follow-up (mean age 12.0 years), with a sample size of n = 2615.

Results

Children living in poorer neighborhoods (higher ADI) showed lower brain WM microstructural integrity at baseline and follow-up, even after adjusting for age, sex, race/ethnicity, head size, body mass index, parental education, and income levels. This reduced microstructure was seen in critical tracts, such as the superior longitudinal fasciculus, corpus callosum, and the uncinate. Additionally, baseline and follow-up rs-fMRI analysis revealed that children living in poorer neighborhoods had decreased connectivity within the retrosplenial-temporal network and between higher-order networks, such as the cingulo-opercular network.

Conclusions

These findings highlight the influence of neighborhood socioeconomic disadvantage on both WM microstructural integrity and functional brain connectivity in the preadolescent brain. Children from more deprived neighborhoods showed reduced integrity in key WM tracts and disrupted connectivity within and between higher-order networks.

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童年邻里剥夺对青春期白质和功能连通性的影响

背景和目的健康的社会经济决定因素影响儿童发展和成人健康结果。一个关键方面是儿童生活和成长的物理环境和社区。新出现的证据表明，通常由区域剥夺指数（ADI）衡量的邻里剥夺可能影响神经发育，但纵向和多模态神经成像分析仍然有限。方法：我们使用来自青少年大脑认知发展研究的具有人口统计学代表性的大型队列，研究了儿童社区与脑白质（WM）微观结构完整性之间的关系。我们分析了基线（平均年龄9.9岁）和随访（平均年龄12.0岁）儿童WM微结构完整性和静息状态功能磁共振成像（rs-fMRI）连通性的ADI与MRI指标之间的关系，样本量为n = 2615。结果生活在较贫困社区的儿童（较高的ADI）在基线和随访时显示出较低的脑WM微观结构完整性，即使在调整了年龄、性别、种族/民族、头大小、体重指数、父母教育程度和收入水平后也是如此。在关键神经束，如上纵束、胼胝体和钩状肌中可以看到这种微结构的减少。此外，基线和随访的rs-fMRI分析显示，生活在贫困社区的儿童在脾后颞叶网络和高阶网络（如扣谷-眼窝网络）之间的连通性下降。结论邻里社会经济劣势对青春期前脑微结构完整性和脑功能连通性的影响。来自更贫困社区的儿童在关键的神经网络中表现出较低的完整性，并破坏了高阶神经网络内部和之间的连通性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!