Green Synthetic Amide-Modified Hyper-Cross-Linked Adsorption Resin for Efficiently Separating Chlorogenic Acid From Eucommia ulmoides Extracts

IF 2.8 3区工程技术 Q2 CHEMISTRY, ANALYTICAL

Journal of separation science Pub Date : 2025-09-08 DOI:10.1002/jssc.70256

Xuefang Chen, Zhijie Shen, Haifeng Chen, Hairong Chen, Tessafa Abrham Ashagrie, Hailong Li, Hairong Zhang, Lian Xiong, Xinde Chen

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Abstract

Eucommia ulmoides Oliver leaf is rich in chlorogenic acid, which has antioxidant, antiviral, and anti-inflammatory activities. In this work, a new and green strategy for functional hyper-crosslinked adsorption resin based on Friedel–Crafts reaction of pendant vinyl groups in divinylbenzene with anhydrous ethanol and acrylamide grafting polymerization was developed, and the obtained HCREt-AM resin had excellent performance on chlorogenic acid separation from Eucommia ulmoides Oliver leaf extract. Adsorption isotherm and kinetics study showed the adsorption process fitted by Langmuir adsorption isotherm and pseudo-second-order kinetic equation. The dynamic saturated adsorption capacity of 88.0 mg·g⁻¹ was obtained, and chlorogenic acid content was raised from 7.91% to 48.27%. The pH-controlled ionization of chlorogenic acid determined the adsorption process, and π-π stacking, hydrophobic interactions, hydrogen bonding, and electrostatic interactions are the main adsorption mechanisms.

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绿色合成酰胺改性超交联吸附树脂高效分离杜仲提取物中的绿原酸

杜仲叶含有丰富的绿原酸，具有抗氧化、抗病毒、抗炎等作用。基于二乙烯基苯中悬垂乙烯基与无水乙醇的Friedel-Crafts反应和丙烯酰胺接枝聚合，开发了一种新型的绿色功能性超交联吸附树脂，所制得的HCREt-AM树脂对杜仲叶提取物中绿原酸具有良好的分离性能。吸附等温线和动力学研究表明，吸附过程符合Langmuir吸附等温线和拟二级动力学方程。动态饱和吸附量为88.0 mg·g−1，绿原酸含量由7.91%提高到48.27%。绿原酸的ph控制电离决定了吸附过程，π-π堆积、疏水相互作用、氢键和静电相互作用是主要的吸附机制。

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来源期刊

Journal of separation science 化学-分析化学

CiteScore

6.30

自引率

16.10%

发文量

408

审稿时长

1.8 months

期刊介绍： The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.