Exploring the therapeutic potential of L-arginine in chronic anal fissure management: a comprehensive review

IF 2.4 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Amino Acids Pub Date : 2025-09-08 DOI:10.1007/s00726-025-03478-x

Nogol Motamed-Gorji, Mohsen Masoodi, Masoumeh Khalighi Sikaroudi, Shahram Agah, Nikta Masoodi

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引用次数: 0

Abstract

Anal fissure causes pain and bleeding during or after bowel movements, significantly impacting individuals’ quality of life. Current treatments aim to interrupt this cycle but have associated risks and limitations. The emergence of arginine, crucial for protein creation and nitric oxide (NO) production, presents an intriguing therapeutic avenue by the impact on reducing anal sphincter pressure and enhancing anoderm blood flow, due to its roles in vasodilation, anti-inflammatory responses, and collagen synthesis, which can promote wound healing and highlighting its potential as an alternative therapy. However, the effectiveness of oral supplementation remains debated, indicating the need for further elucidation of its mechanisms. Its multifaceted mechanisms can present an exciting avenue for nuanced treatments, urging further exploration to refine its role in chronic anal fissure management. This review comprehensively explores the therapeutic landscape of L-arginine in chronic anal fissure management, integrating recent research studies and clinical investigations.

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探索l -精氨酸在慢性肛裂治疗中的治疗潜力：综述

肛裂会在排便时或排便后引起疼痛和出血，严重影响个人的生活质量。目前的治疗旨在中断这一循环，但存在相关的风险和局限性。精氨酸的出现对蛋白质的产生和一氧化氮（NO）的产生至关重要，由于其在血管舒张、抗炎反应和胶原合成中的作用，它可以促进伤口愈合，并突出其作为替代疗法的潜力，它通过降低肛门括约肌压力和增强阳极血流量的影响，提出了一种有趣的治疗途径。然而，口服补充剂的有效性仍然存在争议，表明需要进一步阐明其机制。其多方面的机制可以为细致入微的治疗提供令人兴奋的途径，敦促进一步探索完善其在慢性肛裂治疗中的作用。本文综合近期研究和临床调查，全面探讨了l -精氨酸在慢性肛裂治疗中的治疗前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Amino Acids 生物-生化与分子生物学

CiteScore

6.40

自引率

5.70%

发文量

审稿时长

2.2 months

期刊介绍： Amino Acids publishes contributions from all fields of amino acid and protein research: analysis, separation, synthesis, biosynthesis, cross linking amino acids, racemization/enantiomers, modification of amino acids as phosphorylation, methylation, acetylation, glycosylation and nonenzymatic glycosylation, new roles for amino acids in physiology and pathophysiology, biology, amino acid analogues and derivatives, polyamines, radiated amino acids, peptides, stable isotopes and isotopes of amino acids. Applications in medicine, food chemistry, nutrition, gastroenterology, nephrology, neurochemistry, pharmacology, excitatory amino acids are just some of the topics covered. Fields of interest include: Biochemistry, food chemistry, nutrition, neurology, psychiatry, pharmacology, nephrology, gastroenterology, microbiology