Pilot Study to Assess the Ability of a 4-Week, Home-Based, Electrical Muscle Stimulation Program to Improve Lower Extremity Function and Reduce Sarcopenia in Older Individuals With Cancer

IF 2 Q2 REHABILITATION

Archives of rehabilitation research and clinical translation Pub Date : 2025-09-01 DOI:10.1016/j.arrct.2025.100479

Hisashi Kosaka MD, PhD , Tome Ikezoe MD, PhD , Kimitaka Hase MD, PhD , Yutaka Kimura MD, PhD , Takumi Miyauchi , Tung Thanh Lai MD , Khanh Van Nguyen MD , Kyoko Inoue , Moriyasu Takada , Hideyuki Matsushima MD, PhD , Gozo Kiguchi MD, PhD , Hidekazu Yamamoto MD, PhD , Kosuke Matsui MD, PhD , Megumi Taketani , Tomoyuki Shirai , Masaki Kaibori MD, PhD

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Abstract

Objective

To assess the effectiveness of home-based self-rehabilitation using a portable electrical muscle stimulation (EMS) device for improving severe sarcopenia by improving lower extremity function.

Design

The effect of 4 weeks of EMS training on improving lower extremity function was compared between patients divided into 2 groups based on baseline lower extremity function. Self-rehabilitation was carried out with a portable EMS device, the SIXPAD Foot Fit, and each session lasted 15-23 minutes. Lower extremity function was assessed with the Short Physical Performance Battery (SPPB).

Setting

University hospital.

Participants

The study included 50 older outpatients (N=50) with a mean age of 75 years; 98% had hepatobiliary cancer, and 38% were men.

Interventions

Not applicable.

Main Outcome Measures

Patients were divided into 2 groups based on baseline SPPB value (SPPB ≤ 9 or SPPB >9). Lower extremity function was observed prospectively during 4 weeks of home-based self-rehabilitation.

Results

EMS was used consistently, with a median duration of use of 28 days. In the baseline SPPB>9 group, lower extremity function was not significantly improved (SPPB, 11.0-12.0; P=.290). In contrast, significant improvement was observed in the baseline SPPB ≤ 9 group, and the total score (SPPB score, 8.0-9.0; P=.001) and 2 of its 3 components, balance (balance score, 3.0-4.0; P=.009) and gait speed (gait speed score, 3.0-4.0; P=.002), improved significantly. Sit-to-stand ability did not improve (Sit-to-stand score, 1.0-2.0; P=.060). As a result, the proportion of patients with severe sarcopenia was initially 66.7% but decreased significantly to 36.4% (P=.002).

Conclusions

A home-based, self-rehabilitation program using a portable EMS device may improve lower extremity function and attenuate sarcopenic status in older patients with cancer with reduced lower extremity function.

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评估为期4周的家庭肌肉电刺激计划改善老年癌症患者下肢功能和减少肌肉减少症能力的初步研究

目的评价便携式肌肉电刺激（EMS）装置在家自我康复通过改善下肢功能改善重度肌少症的疗效。设计比较4周EMS训练对改善下肢功能的效果，并以下肢功能基线分为两组。自我康复使用便携式EMS设备SIXPAD Foot Fit进行，每次持续15-23分钟。用短物理性能电池（SPPB）评估下肢功能。SettingUniversity医院。参与者：该研究包括50例老年门诊患者（N=50），平均年龄为75岁；98%为肝胆癌，其中38%为男性。InterventionsNot适用。根据SPPB基线值（SPPB≤9或SPPB >；9）将患者分为两组。在为期4周的居家自我康复期间，对下肢功能进行前瞻性观察。结果ems持续使用，平均使用时间为28天。基线SPPB>；9组下肢功能无明显改善（sppb11.0 -12.0； P= 0.290）。相比而言，基线SPPB≤9组有明显改善，SPPB总分（8.0 ~ 9.0分，P= 0.001）、平衡（平衡评分3.0 ~ 4.0分，P= 0.009）、步速（步速评分3.0 ~ 4.0分，P= 0.002）及总得分（SPPB评分8.0 ~ 9.0分，P= 0.001）均有显著改善。坐立能力没有提高（坐立得分1.0 ~ 2.0；P= 0.060）。结果，重度肌肉减少症患者的比例从最初的66.7%下降到36.4% （P= 0.002）。结论采用便携式EMS装置进行居家自我康复治疗可改善老年癌症伴下肢功能减退患者的下肢功能，减轻其肌少症症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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