Yue Wang , Hui Fang , Guofeng Zhou , Guanzhao Zhang , Xiao Wang , Zhiyong Zhang , Yingjie Zhao , Bo Li
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引用次数: 0
Abstract
Impaired chronic wound healing in diabetes remains a significant clinical problem, with excessive oxidative stress being a major cause of the delay. In this study, we developed a water-soluble 6HPB@C60 complex by encapsulating fullerene C60 molecules within a cubic supramolecular cage 6HPB. Subsequently, 6HPB@C60 was loaded in the sodium alginate hydrogel to create an antioxidant system (6HPB@C60 gel) for diabetic wound healing. 6HPB@C60 gel exhibits a homogeneous and interconnected porous microstructure, demonstrating excellent tissue adhesion, low cytotoxicity, and excellent antioxidant capacity. Diabetic chronic wounds heal faster with 6HPB@C60 gel, which eliminates reactive oxygen species continuously. By regulating macrophage polarization, pro-inflammatory states are reduced, while at the same time cell proliferation, epithelialization, and collagen deposition and alignment are also facilitated. In conclusion, a possible solution for chronic wound management can be found in the 6HPB@C60 gel, which works significantly to accelerate diabetic wound closure and improve wound quality.
期刊介绍:
Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).