Hydrogels loaded with aqueous supramolecular fullerene complex for the promotion of diabetic chronic wound healing

IF 10.2 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Yue Wang , Hui Fang , Guofeng Zhou , Guanzhao Zhang , Xiao Wang , Zhiyong Zhang , Yingjie Zhao , Bo Li
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Abstract

Impaired chronic wound healing in diabetes remains a significant clinical problem, with excessive oxidative stress being a major cause of the delay. In this study, we developed a water-soluble 6HPB@C60 complex by encapsulating fullerene C60 molecules within a cubic supramolecular cage 6HPB. Subsequently, 6HPB@C60 was loaded in the sodium alginate hydrogel to create an antioxidant system (6HPB@C60 gel) for diabetic wound healing. 6HPB@C60 gel exhibits a homogeneous and interconnected porous microstructure, demonstrating excellent tissue adhesion, low cytotoxicity, and excellent antioxidant capacity. Diabetic chronic wounds heal faster with 6HPB@C60 gel, which eliminates reactive oxygen species continuously. By regulating macrophage polarization, pro-inflammatory states are reduced, while at the same time cell proliferation, epithelialization, and collagen deposition and alignment are also facilitated. In conclusion, a possible solution for chronic wound management can be found in the 6HPB@C60 gel, which works significantly to accelerate diabetic wound closure and improve wound quality.

Abstract Image

负载水超分子富勒烯复合物的水凝胶促进糖尿病慢性伤口愈合
糖尿病慢性伤口愈合受损仍然是一个重要的临床问题,过度的氧化应激是延迟的主要原因。在这项研究中,我们通过将富勒烯C60分子封装在一个立方超分子笼6HPB中,开发了一种水溶性6HPB@C60配合物。随后,将6HPB@C60装入海藻酸钠水凝胶中,以创建用于糖尿病伤口愈合的抗氧化系统(6HPB@C60凝胶)。6HPB@C60凝胶具有均匀且相互连接的多孔微观结构,具有优异的组织粘附性、低细胞毒性和优异的抗氧化能力。糖尿病慢性伤口愈合更快6HPB@C60凝胶,它可以持续消除活性氧。通过调节巨噬细胞极化,减少促炎状态,同时促进细胞增殖、上皮化、胶原沉积和排列。总之,6HPB@C60凝胶可能是慢性伤口管理的一种解决方案,它可以显著加速糖尿病伤口愈合,提高伤口质量。
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来源期刊
CiteScore
8.30
自引率
4.90%
发文量
303
审稿时长
30 days
期刊介绍: Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).
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