Yi Yang , Wenjie Huang , Jingjing Shi , Bei Tian , Caihong Fu , Jianxi Xiao
{"title":"Bioactive recombinant human elastin gel for reconstructing elastic fibers and rejuvenating endogenously aged skin","authors":"Yi Yang , Wenjie Huang , Jingjing Shi , Bei Tian , Caihong Fu , Jianxi Xiao","doi":"10.1016/j.mtbio.2025.102270","DOIUrl":null,"url":null,"abstract":"<div><div>Endogenous skin aging results in oxidative stress and degradation of elastic fibers, leading to reduced skin elasticity and dermal laxity. Current treatments rarely target elastic fiber regeneration. Here, we introduce a bioactive gel containing recombinant humanized elastin (RHE) that effectively restores skin elasticity and promotes extracellular matrix remodeling. RHE gel demonstrated superior efficacy in reversing UV-induced damage and oxidative stress in zebrafish models, and significantly improved skin function in aged mice, outperforming commercial vitamin E and recombinant humanized collagen (RHC) gels. Molecular analyses revealed enhanced expression of key elastic fiber and collagen components alongside reduced matrix-degrading enzymes. This study highlights RHE gel's potential as a novel therapeutic for regenerative dermatology and skin aging.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102270"},"PeriodicalIF":10.2000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Today Bio","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590006425008403","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Endogenous skin aging results in oxidative stress and degradation of elastic fibers, leading to reduced skin elasticity and dermal laxity. Current treatments rarely target elastic fiber regeneration. Here, we introduce a bioactive gel containing recombinant humanized elastin (RHE) that effectively restores skin elasticity and promotes extracellular matrix remodeling. RHE gel demonstrated superior efficacy in reversing UV-induced damage and oxidative stress in zebrafish models, and significantly improved skin function in aged mice, outperforming commercial vitamin E and recombinant humanized collagen (RHC) gels. Molecular analyses revealed enhanced expression of key elastic fiber and collagen components alongside reduced matrix-degrading enzymes. This study highlights RHE gel's potential as a novel therapeutic for regenerative dermatology and skin aging.
期刊介绍:
Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).