Assessing diagnostic, vaccine and therapeutic potential of selected Trichinella proteins

IF 3.1 Q2 PARASITOLOGY

Food and Waterborne Parasitology Pub Date : 2025-09-01 DOI:10.1016/j.fawpar.2025.e00283

Anna Stachyra , Justyna Bień-Kalinowska

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Abstract

Trichinellosis is an important zoonotic parasitosis caused by nematodes of the genus Trichinella. In humans, Trichinella infection occurs through the ingestion of raw or semi-cooked meat of animals infected with Trichinella spp. larvae, as the causative agent. Over the past decade, technological developments have enabled great achievements in the study of the genome, secretome and proteome of Trichinella. These achievements provide knowledge to screen, identify, and compare the proteins and antigens involved in the host-parasite communication and interactions with the host's immune system and thus constituting diagnostic, vaccine, or therapeutic targets. Much attention has been focused on identifying and characterizing proteins from different Trichinella stages to find molecules useful for serodiagnosis and vaccine development. This review presents a number of recombinant proteins examined as candidates for diagnosis of Trichinella infection. However, antigens suitable for improved early diagnosis or detection are not yet available. Identification of potential vaccine candidates against trichinellosis remains a significant challenge. Various recombinant protein vaccines have been reviewed to improve the protective effect against Trichinella infection in mice, rat or swine models. A considerable amount of research has investigated the immunomodulatory potential of Trichinella proteins. The application of total ES products as well as individual components in recombinant form, showed that they exert strong immunomodulatory effects and can act prophylactically or therapeutically in animal models of autoimmune diseases. This paper provides an overview and summary of recent achievements in the field of Trichinella recombinant proteins, emphasizing their potential application to diagnosis, vaccination, and modulation of allergy and oncogenesis.

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评估选定旋毛虫蛋白的诊断、疫苗和治疗潜力

旋毛虫病是由旋毛虫属线虫引起的一种重要的人畜共患寄生虫病。在人类中，旋毛虫感染是通过食用被旋毛虫幼虫感染的动物的生的或半熟的肉而发生的，旋毛虫幼虫是病原体。在过去的十年中，技术的发展使旋毛虫的基因组、分泌组和蛋白质组的研究取得了巨大的成就。这些成果为筛选、鉴定和比较参与宿主-寄生虫交流和与宿主免疫系统相互作用的蛋白质和抗原提供了知识，从而构成诊断、疫苗或治疗靶点。许多注意力都集中在鉴定和表征旋毛虫不同阶段的蛋白质上，以寻找对血清诊断和疫苗开发有用的分子。本文综述了一些重组蛋白作为诊断旋毛虫感染的候选物。然而，目前还没有适合改善早期诊断或检测的抗原。确定潜在的旋毛虫病候选疫苗仍然是一项重大挑战。各种重组蛋白疫苗已经在小鼠、大鼠或猪模型上进行了综述，以提高对旋毛虫感染的保护作用。相当多的研究已经调查了旋毛虫蛋白的免疫调节潜力。通过对ES总产物以及重组形式的单个组分的应用表明，它们具有很强的免疫调节作用，在自身免疫性疾病的动物模型中具有预防或治疗作用。本文综述了旋毛虫重组蛋白研究的最新进展，重点介绍了其在诊断、疫苗接种、过敏和肿瘤发生调节等方面的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food and Waterborne Parasitology Immunology and Microbiology-Parasitology

CiteScore

5.10

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Food and Waterborne Parasitology publishes high quality papers containing original research findings, investigative reports, and scientific proceedings on parasites which are transmitted to humans via the consumption of food or water. The relevant parasites include protozoa, nematodes, cestodes and trematodes which are transmitted by food or water and capable of infecting humans. Pertinent food includes products of animal or plant origin which are domestic or wild, and consumed by humans. Animals and plants from both terrestrial and aquatic sources are included, as well as studies related to potable and other types of water which serve to harbor, perpetuate or disseminate food and waterborne parasites. Studies dealing with prevalence, transmission, epidemiology, risk assessment and mitigation, including control measures and test methodologies for parasites in food and water are of particular interest. Evidence of the emergence of such parasites and interactions among domestic animals, wildlife and humans are of interest. The impact of parasites on the health and welfare of humans is viewed as very important and within scope of the journal. Manuscripts with scientifically generated information on associations between food and waterborne parasitic diseases and lifestyle, culture and economies are also welcome. Studies involving animal experiments must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences.