Assessing the burden of congenital toxoplasmosis in Burundi, 2020

IF 2.5 3区医学 Q2 PARASITOLOGY

Acta tropica Pub Date : 2025-09-05 DOI:10.1016/j.actatropica.2025.107828

Salvator Minani , Carlotta Di Bari , Brecht Devleesschauwer , Anastasie Gasogo , Jean-Bosco Ntirandekura , Sarah Gabriël , Chiara Trevisan

{"title":"Assessing the burden of congenital toxoplasmosis in Burundi, 2020","authors":"Salvator Minani , Carlotta Di Bari , Brecht Devleesschauwer , Anastasie Gasogo , Jean-Bosco Ntirandekura , Sarah Gabriël , Chiara Trevisan","doi":"10.1016/j.actatropica.2025.107828","DOIUrl":null,"url":null,"abstract":"<div><div>Congenital toxoplasmosis (CT) due to <em>Toxoplasma gondii</em>, an apicomplexan parasite, leads to significant sequelae in children, foetal losses and neonatal deaths worldwide. This study aimed to assess the burden of CT in Burundi for the year 2020. We used epidemiological and economic data collected in major hospitals in Burundi, the Ministry of Public Health in Burundi and international peer-reviewed literature to estimate the disability-adjusted life years (DALYs) and economic costs spent on prenatal consultations, diagnosis and treatment of toxoplasmosis for pregnant women. In Burundi, the incidence of CT in 2020 was 2.7 cases per 1000 children (95 % UI: 1.8–3.7) and 1180 children (95 % UI: 797–1633) were born with CT. The health burden due to CT in 2020 was estimated at 7283 DALYs (95 % UI: 4469–10,920) when including and 3671 DALYs (95 % UI: 2286–5547) when excluding foetal losses, respectively. Approximately 550,000 USD (95 % UI: 222,027–1088,331) were economic losses due to CT in 2020, with 690 USD (95 % UI: 375–1002) per pregnant woman receiving treatment until delivery and 31 USD (95 % UI: 10–70) for an untreated one. This study demonstrates that CT is a significant public health concern in Burundi. However, due to data gaps, uncertainties in DALY and economic cost estimates remain. Control measures, including proper meat cooking, improved hygiene and sanitation practices, better management of cats and their faeces, routine diagnostic check-ups for pregnant women, and timely treatment for infected pregnant women, are crucial to reduce the health and economic burden of toxoplasmosis in Burundi.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"270 ","pages":"Article 107828"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta tropica","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0001706X25002980","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Congenital toxoplasmosis (CT) due to Toxoplasma gondii, an apicomplexan parasite, leads to significant sequelae in children, foetal losses and neonatal deaths worldwide. This study aimed to assess the burden of CT in Burundi for the year 2020. We used epidemiological and economic data collected in major hospitals in Burundi, the Ministry of Public Health in Burundi and international peer-reviewed literature to estimate the disability-adjusted life years (DALYs) and economic costs spent on prenatal consultations, diagnosis and treatment of toxoplasmosis for pregnant women. In Burundi, the incidence of CT in 2020 was 2.7 cases per 1000 children (95 % UI: 1.8–3.7) and 1180 children (95 % UI: 797–1633) were born with CT. The health burden due to CT in 2020 was estimated at 7283 DALYs (95 % UI: 4469–10,920) when including and 3671 DALYs (95 % UI: 2286–5547) when excluding foetal losses, respectively. Approximately 550,000 USD (95 % UI: 222,027–1088,331) were economic losses due to CT in 2020, with 690 USD (95 % UI: 375–1002) per pregnant woman receiving treatment until delivery and 31 USD (95 % UI: 10–70) for an untreated one. This study demonstrates that CT is a significant public health concern in Burundi. However, due to data gaps, uncertainties in DALY and economic cost estimates remain. Control measures, including proper meat cooking, improved hygiene and sanitation practices, better management of cats and their faeces, routine diagnostic check-ups for pregnant women, and timely treatment for infected pregnant women, are crucial to reduce the health and economic burden of toxoplasmosis in Burundi.

查看原文本刊更多论文

评估布隆迪2020年先天性弓形虫病负担

由弓形虫引起的先天性弓形虫病（CT）是一种顶复合体寄生虫，在世界范围内导致严重的儿童后遗症、胎儿损失和新生儿死亡。本研究旨在评估布隆迪2020年CT负担。我们使用从布隆迪主要医院、布隆迪公共卫生部和国际同行评审文献中收集的流行病学和经济数据来估计孕妇在弓形虫病产前咨询、诊断和治疗上花费的残疾调整生命年（DALYs）和经济成本。在布隆迪，2020年的CT发病率为每1000名儿童2.7例（95% UI: 1.8-3.7）， 1180名儿童（95% UI: 797-1633）出生时患有CT。2020年CT造成的健康负担估计分别为7283个DALYs （95% UI: 4469-10,920）和3671个DALYs (95% UI: 2286-5547)，其中包括胎儿损失。2020年因CT造成的经济损失约为55万美元（95% UI: 222,027 - 1088,331），其中每名接受治疗至分娩的孕妇为690美元（95% UI: 375-1002），未接受治疗的孕妇为31美元（95% UI: 10-70）。这项研究表明，CT在布隆迪是一个重大的公共卫生问题。然而，由于数据缺口，DALY和经济成本估算仍然存在不确定性。控制措施，包括适当的肉类烹调、改善个人卫生和环境卫生做法、更好地管理猫及其粪便、对孕妇进行常规诊断检查以及及时治疗受感染的孕妇，对于减轻布隆迪弓形虫病的健康和经济负担至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta tropica 医学-寄生虫学

CiteScore

5.40

自引率

11.10%

发文量

383

审稿时长

37 days

期刊介绍： Acta Tropica, is an international journal on infectious diseases that covers public health sciences and biomedical research with particular emphasis on topics relevant to human and animal health in the tropics and the subtropics.