The structure and function of FBXW5 in human diseases

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-09-08 DOI:10.1016/j.bbrep.2025.102252

Yuyang Han, Tao Yu, Zhaowu Ma

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Abstract

FBXW5, a member of the F-box protein family, plays a pivotal role in various cellular processes through its involvement in ubiquitin-mediated proteolysis as a component of the SCF complex. Recent studies have highlighted the potential of targeting FBXW5 for therapeutic interventions, making it a promising candidate for drug development. Thus, it is of great importance to provide a comprehensive overview of the structure and function of FBXW5, with a particular focus on its binding motifs for gene regulation and activities to recruitment and recognition. Herein, this review summarizes the biological significance of FBXW5 in different diseases, including cancers, neurological disorders, and other pathological conditions. This review also discusses the current challenges and future perspectives in research on FBXW5 in human diseases. Although direct inhibitors are lacking, therapeutic vulnerability is achieved via SCF inhibition or targeting hyperactivated downstream signaling nodes, emphasizing the need for further studies to fully elucidate its biological functions and therapeutic potential.

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FBXW5在人类疾病中的结构和功能

FBXW5是F-box蛋白家族的一员，作为SCF复合物的组成部分，通过参与泛素介导的蛋白水解，在各种细胞过程中发挥关键作用。最近的研究强调了FBXW5靶向治疗干预的潜力，使其成为药物开发的有希望的候选者。因此，全面了解FBXW5的结构和功能，重点研究FBXW5的结合基序在基因调控和基因募集和识别中的作用具有重要意义。本文综述了FBXW5在不同疾病中的生物学意义，包括癌症、神经系统疾病和其他病理状况。本文还讨论了FBXW5在人类疾病中的研究面临的挑战和未来前景。虽然缺乏直接抑制剂，但治疗脆弱性是通过抑制SCF或靶向超激活的下游信号节点来实现的，强调需要进一步研究以充分阐明其生物学功能和治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.