Isolated lumbar vertebral infection caused by Coxiella burnetii: A case report and literature review

IF 1.8 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-09-03 DOI:10.1016/j.diagmicrobio.2025.117097

Mingming Xin, Xiaohui Wang, Minggui Lin, Xuzhu Ma

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Abstract

This study describes the clinical characteristics and treatment of vertebral infection caused by Coxiella burnetii through a case report and literature review. We present a 60-year-old male with isolated lumbar vertebral infection. A comprehensive literature review identified 17 cases, with 82.4 % of patients over 50 years old. Common symptoms included lumbar pain and fever, while 52.9 % developed adjacent vertebral infections through abdominal aortic aneurysms. Only 17.6 % presented as isolated vertebral infections. Radiological evidence of vertebral destruction was observed in all cases, with no cardiac valve involvement. Treatment involved doxycycline, hydroxychloroquine, fluoroquinolones, rifampicin, and surgical intervention, resulting in favorable outcomes. Isolated vertebral infections caused by Coxiella burnetii are extremely rare and pose significant diagnostic challenges. Early surgical intervention, effective diagnostic methods, and standardized anti-infective therapy are crucial for management. This case highlights the importance of timely diagnosis and multidisciplinary treatment for this rare condition.

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孤立性伯纳克希菌腰椎感染1例并文献复习

本研究通过病例报告和文献回顾，阐述了伯纳克希菌引起椎体感染的临床特点和治疗方法。我们提出一个60岁男性孤立腰椎感染。综合文献回顾发现17例，其中82.4%的患者年龄在50岁以上。常见症状包括腰痛和发热，而52.9%的患者通过腹主动脉瘤发生相邻椎体感染。只有17.6%表现为孤立的椎体感染。所有病例均观察到椎体破坏的影像学证据，无心脏瓣膜受累。治疗包括强力霉素、羟氯喹、氟喹诺酮类药物、利福平和手术干预，结果良好。由伯纳氏克希菌引起的孤立椎体感染极为罕见，并构成重大的诊断挑战。早期手术干预、有效的诊断方法和标准化的抗感染治疗是治疗的关键。这个病例强调了及时诊断和多学科治疗这种罕见疾病的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.