RNA-binding proteins pull in chromatin loops

IF 19.1 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-09-08 DOI:10.1038/s41556-025-01743-5

Ann Dean

引用次数: 0

Abstract

During development as cells exit a pluripotent state, chromatin looping interactions are strengthened, but the mechanism for this is unknown. A study now shows that CTCF–RBP interactions increase upon differentiation of embryonic stem cells to neural stem cells, and that the non-coding RNA Pantr1 collaborates with CTCF and RBPs to contract the genome.

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rna结合蛋白拉入染色质环

在发育过程中，当细胞退出多能状态时，染色质环的相互作用得到加强，但其机制尚不清楚。现在一项研究表明，在胚胎干细胞向神经干细胞分化过程中，CTCF - rbp相互作用增加，非编码RNA Pantr1与CTCF和rbp合作收缩基因组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology