Ovarian mature teratomas: Differences in management and outcomes in adolescents cared for by gynecologic and pediatric surgeons

IF 0.8 4区医学 Q4 ONCOLOGY

Bulletin Du Cancer Pub Date : 2025-09-05 DOI:10.1016/j.bulcan.2025.04.016

Iliasse Baatti , Fanny Delehaye , Sabine Sarnacki , Christine Denoual Ziad , Frédéric Hameury , Estelle Aubry , Edouard Habonimana , Solène Joseph , Aurélien Scalabre , Yann Chaussy , Guillaume Podevin , Quentin Ballouhey , Frédéric Lavrand , Matthieu Peycelon , Sabine Irtan , Florent Guérin , Anne Dariel , Claude Borrione , Louise Galmiche , Elodie Haraux , Julien Rod

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引用次数: 0

Abstract

Background

Ovarian mature teratomas (OMTs) are the most common benign ovarian tumors in pediatric patients. Management in adolescents can be performed by pediatric (PSs) or gynecologic surgeons (GSs). The aim of this study was to assess the differences in OMT management and the repercussions according to the risk of secondary events.

Design

Based on a multicentric study, we compared patients aged 14 to 18 who underwent surgery for OMT between 2009 and 2022 from the French national pediatric database of OMTs with patients managed by GSs.

Results

In total, 119 patients were included (80 by PSs, 39 by GSs). Differences between teams were noted: (i) tumor marker analysis is systematic by PSs (80%, n = 72) but rare by GSs (18%, n = 7) (P < 0.001), (ii) PSs mostly carried out a laparotomy (78%, n = 62), whereas GSs preferred laparoscopy (90%, n = 35) (P < 0.001), (iii) peroperative rupture was more frequent by GSs (56%, n = 22) than PSs (10%, n = 8) (P < 0.001), (iv) median duration of follow-up increased by PSs (20 months) versus 1 month by GSs (P = 0.001). Ten second events (13% by GSs [n = 5], 6% by PSs [n = 5]) occurred in nine patients, without significant differences (P = 0.151).

Conclusion

A notable difference exists in the management of OMTs between PSs and GSs in our study, GSs may overlook a malignant component in germ cell tumors in adolescents and the risk of metachronous recurrence, reported up to 10–20%. We recommend a compliance to SIOPE 2020 guidelines (Sessa et al., 2020) to avoid rupture of potential malignant tumor and to preserve fertility.

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卵巢成熟畸胎瘤：由妇科和儿科外科医生照顾的青少年的管理和结果的差异。

背景：卵巢成熟畸胎瘤（OMTs）是儿科患者最常见的良性卵巢肿瘤。青少年的管理可以由儿科（PSs）或妇科外科医生（GSs）进行。本研究的目的是根据次要事件的风险评估OMT管理的差异和影响。设计：基于一项多中心研究，我们比较了2009年至2022年期间法国国家儿科OMT数据库中14至18岁接受OMT手术的患者与由GSs管理的患者。结果：共纳入119例患者（ps80例，GSs 39例）。(1) PSs对肿瘤标志物的系统性分析（80%,n=72），而GSs对肿瘤标志物的系统性分析（18%,n=7） (p)结论：在我们的研究中，PSs和GSs对omt的管理存在显著差异，GSs可能忽略了青少年生殖细胞肿瘤的恶性成分和异时性复发的风险，据报道高达10-20%。我们建议遵守SIOPE 2020指南（Sessa等，2020），以避免潜在恶性肿瘤破裂并保持生育能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin Du Cancer 医学-肿瘤学

CiteScore

1.90

自引率

16.70%

发文量

224

审稿时长

37 days

期刊介绍： Without doubt, the ''Bulletin du Cancer'' is the French language publication of reference in the field of cancerology. Official organ of the French Society of Cancer, this journal covers all the information available, whether in the form of original articles or review articles, but also clinical cases and letters to the editor, including various disciplines as onco-hematology, solids tumors, medical oncology, pharmacology, epidemiology, biology as well as fundamental research in cancerology. The journal proposes a clinical and therapeutic approach of high scientific standard and regular updates in knowledge are thus made possible. Articles can be submitted in French or English.