Feasibility and Effectiveness of Yttrium-90 Radioembolization in Normal Lung Parenchyma: A Preclinical Study in Rabbits with Pathological Correlation to Absorbed Dose.

IF 2.6 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Vascular and Interventional Radiology Pub Date : 2025-09-04 DOI:10.1016/j.jvir.2025.08.044

Ioannis Spyridonidis, Marios Platon Dimopoulos, Pinelopi Bosgana, Trifon Spyridonidis, Theodoros Skouras, Michalis Theofanis, Christos Papageorgiou, Nikolaos Giannikas, Panagiotis M Kitrou, Konstantinos Katsanos, Dimitrios Karnabatidis

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引用次数: 0

Abstract

This study investigated the effects of yttrium-90 (⁹⁰Y) radioembolization in 8 rabbits, focusing on delivery accuracy, dosimetry, and pathological outcomes. ⁹⁰Y was successfully delivered angiographically targeted via the pulmonary lower basal segmental arteries to all rabbits, with confirmation via positron emission tomography (PET)/computed tomography (CT) imaging and a lung target median of the mean dose of 132.1 Gy (range, 11.2-262.3 Gy). Pathological analysis in all surviving subjects revealed complete necrosis of the irradiated segments, with associated inflammation in adjacent nonirradiated tissue. Radiological follow-up with CT scan showed triangular fibrosis in 6 rabbits at 1 month, progressing to fibrosis at 3 months. Dosimetry analysis confirmed dose distribution to the targeted lung regions. Of 8 rabbits, 1 died intraprocedurally, and another died 1.5 weeks after the procedure for unknown reasons. The remaining rabbits had no severe adverse events, with 1 case of pleural effusion resolving with no intervention at 3 months. The study demonstrated the feasibility of ⁹⁰Y delivery to the lungs.

查看原文本刊更多论文

钇-90放射栓塞正常肺实质的可行性及疗效：与吸收剂量病理相关的兔临床前研究。

本研究在8只家兔中研究了钇-90 （Y90）放射栓塞的效果，重点研究了传递准确性、剂量学和病理结果。所有家兔均成功通过肺下基段动脉血管造影靶向给予Y90， PET/CT成像证实，肺靶中位平均剂量132.1Gy（范围11.2-262.3Gy）。所有存活受试者的病理分析显示辐照节段完全坏死，邻近未辐照组织伴有相关炎症。放射学随访和ct扫描显示6只兔在1个月时呈三角形纤维化，在3个月时进展为纤维化。剂量学分析证实剂量分布到靶肺区域。在8只兔子中，一只在手术中死亡，另一只在手术后1.5周死亡，原因不明。其余兔无并发症，1例胸腔积液在3个月时无干预解决。该研究证明了将Y90输送到肺部的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular and Interventional Radiology 医学-核医学

CiteScore

4.30

自引率

10.30%

发文量

942

审稿时长

90 days

期刊介绍： JVIR, published continuously since 1990, is an international, monthly peer-reviewed interventional radiology journal. As the official journal of the Society of Interventional Radiology, JVIR is the peer-reviewed journal of choice for interventional radiologists, radiologists, cardiologists, vascular surgeons, neurosurgeons, and other clinicians who seek current and reliable information on every aspect of vascular and interventional radiology. Each issue of JVIR covers critical and cutting-edge medical minimally invasive, clinical, basic research, radiological, pathological, and socioeconomic issues of importance to the field.