The role of lipid metabolism disorder in the progression and treatment of ocular vascular diseases.

IF 5.9 2区 医学 Q1 OPHTHALMOLOGY
Weichen Song, Wen Chen, Jingyi Chi, Xinyu Liu, Wenwen Zhu
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引用次数: 0

Abstract

Lipid metabolism plays a critical role in maintaining normal physiological functions and is strongly linked to the pathogenesis of ocular vascular diseases. We examine how disorders of lipid metabolism drive progression in ocular vascular diseases, including diabetic retinopathy, age-related macular degeneration, retinal vascular occlusive diseases, and retinopathy of prematurity. These disorders are classified as a related group due to their common feature of impaired ocular vascularization. Glaucoma has also been increasingly recognized as a condition resulting from both retinal and choroidal blood flow abnormalities, with shared lipid metabolism disturbances contributing to its pathogenesis. Lipid components such as fatty acids may exacerbate retinal and choroidal damage by promoting neovascularization and inflammatory responses. Additionally, lipid metabolic dysregulation negatively influences the retinal and choroidal microenvironment by increasing oxidative stress and inhibiting autophagy. We also discuss emerging therapeutic strategies targeting lipid metabolism, highlighting their potential in preventing or mitigating ocular vascular diseases. These include lipid-modulating agents and their use in combination with established therapies. Understanding the influence of lipid metabolism on the pathophysiology of these diseases could pave the way for the development of novel treatment approaches. These advancements hold potential to improve visual prognosis in patients with ocular vascular diseases. Identifying the specific roles and molecular targets associated with lipid metabolism in ocular vascular diseases will offer valuable insights into disease mechanisms. This knowledge will lay the groundwork for personalized and more effective clinical interventions.

脂质代谢紊乱在眼部血管疾病进展和治疗中的作用。
脂质代谢在维持正常生理功能中起着至关重要的作用,与眼部血管疾病的发病机制密切相关。本文综述了脂质代谢紊乱如何驱动眼部血管疾病的进展,包括糖尿病视网膜病变、年龄相关性黄斑变性、视网膜血管闭塞性疾病和早产儿视网膜病变。这些疾病因其眼部血管受损的共同特征而被归类为一个相关组。青光眼也越来越被认为是由视网膜和脉络膜血流异常引起的一种疾病,其发病机制与脂质代谢紊乱有关。脂质成分如脂肪酸可通过促进新生血管和炎症反应加重视网膜和脉络膜损伤。此外,脂质代谢失调通过增加氧化应激和抑制自噬对视网膜和脉络膜微环境产生负面影响。本文还讨论了针对脂质代谢的新兴治疗策略,强调了它们在预防或减轻眼部血管疾病方面的潜力。这些包括脂质调节剂及其与现有疗法的联合使用。了解脂质代谢对这些疾病病理生理的影响可以为开发新的治疗方法铺平道路。这些进展有可能改善眼部血管疾病患者的视力预后。确定眼部血管疾病中脂质代谢相关的特定作用和分子靶点将为疾病机制提供有价值的见解。这些知识将为个性化和更有效的临床干预奠定基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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