Odoribacter splanchnicus bacteremia: a rare condition associated with intestinal disease

IF 2.6 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2025-09-04 DOI:10.1016/j.anaerobe.2025.102994

Hiroshi Umemura , Hirokazu Kobayashi , Yumiko Tanimichi , Hiroyuki Nishiyama , Natsumi Ikumi , Masaki Nakajima , Sachio Tsuchida , Tomohiro Nakayama

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引用次数: 0

Abstract

Odoribacter splanchnicus is an anaerobe that normally inhabits the human intestine and rarely causes infections in humans. In recent years, however, three cases of O. splanchnicus bacteremia have been reported. We retrospectively searched our laboratory information system and detected five cases of O. splanchnicus bacteremia in 2014–2024. All cases of O. splanchnicus bacteremia reported to date have been associated with intestinal infection, but our five cases included one associated with decubitus ulcer infection. Antimicrobial susceptibility testing results were available in four of our five cases. O. splanchnicus showed susceptibility to beta-lactams and metronidazole. However, one isolate was resistant to clindamycin, and another showed intermediate susceptibility to levofloxacin. Among our five cases and the three previously reported cases, no patient was using immunosuppressive agents or had immunocompromising diseases except for one case with malignancy. While O. splanchnicus bacteremia is certainly rare, more cases may be found by searching the laboratory information system as in this investigation. Further accumulation of cases will help to elucidate the pathogenesis of infections caused by O. splanchnicus, which is endemic in the gastrointestinal tract, and will reveal more information on antimicrobial susceptibility.

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内脏臭杆菌菌血症：一种与肠道疾病相关的罕见疾病。

内脏臭杆菌是一种常见于人体肠道的厌氧菌，很少引起人体感染。然而，近年来报道了三例内脏O.菌血症。回顾性检索实验室信息系统，2014-2024年共检出5例内脏弓形虫菌血症。迄今为止报道的所有内脏单胞菌菌血症病例都与肠道感染有关，但我们的5例病例中有一例与褥疮感染有关。我们的5个病例中有4个获得了抗菌药物敏感性试验结果。对-内酰胺类和甲硝唑敏感。然而，一株对克林霉素耐药，另一株对左氧氟沙星有中等敏感性。在我们的5例病例和先前报道的3例病例中，除1例恶性肿瘤外，没有患者使用免疫抑制剂或患有免疫功能低下疾病。虽然O. spplanchnicus菌血症当然是罕见的，但在本调查中，通过搜索实验室信息系统可能会发现更多病例。进一步的病例积累将有助于阐明肠道地方病O. spplanchnicus感染的发病机制，并将揭示更多的抗菌药物敏感性信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.