Diagnostic Accuracy and Clinical Impact of Ultrasound-Guided Percutaneous Lung Biopsy in Pediatric Patients: A Retrospective Observational Study.

IF 2.6 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Vascular and Interventional Radiology Pub Date : 2025-09-03 DOI:10.1016/j.jvir.2025.08.040

Jiaojiao Ding, Xin Ni, Xiao Zhang, Jiabin Wan, Wenyuan Shi

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引用次数: 0

Abstract

Purpose: To evaluate the diagnostic accuracy, safety, and clinical impact of ultrasound-guided percutaneous lung biopsy (US-PLB) in pediatric peripheral lung lesions.

Materials and methods: A retrospective cohort analysis included 34 pediatric patients (24 male, 10 female; mean age 7.9 ± 4.4 years) undergoing US-PLB from March 2019 to February 2024. Diagnostic metrics (sensitivity, specificity, positive and negative predictive values) and adverse events were analyzed. The influence of biopsy results on clinical management was assessed.

Results: Among 33 diagnostic procedures, US-PLB demonstrated an accuracy of 97.0% (32/33), with sensitivity of 80.0% (4/5 malignant lesions) and specificity of 100% (28/28 benign lesions). Minor complications occurred in 17.6% (6/34) of patients, including pneumothorax (2.9%) and transient hemoptysis (2.9%). Biopsy findings directly altered therapeutic strategies in 44.1% (15/34) of cases, including initiation of chemotherapy or targeted antimicrobial therapy.

Conclusion: US-PLB is a safe and accurate radiation-free diagnostic technique for pediatric peripheral lung lesions, offering critical histopathologic and microbiologic guidance for clinical decision-making.

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超声引导下儿科患者经皮肺活检的诊断准确性和临床影响：一项回顾性观察研究。

目的：评价超声引导下经皮肺活检（US-PLB）诊断小儿周围性肺病变的准确性、安全性和临床意义。材料和方法：回顾性队列分析包括2019年3月至2024年2月接受US-PLB的34例儿科患者（男24例，女10例，平均年龄7.9±4.4岁）。分析诊断指标（敏感性、特异性、阳性和阴性预测值）和不良事件。评估活检结果对临床处理的影响。结果：在33种诊断方法中，US-PLB的准确率为97.0%(32/33)，敏感性为80.0%（4/5个恶性病变），特异性为100%（28/28个良性病变）。17.6%（6/34）的患者出现轻微并发症，包括气胸（2.9%）和一过性咯血（2.9%）。活检结果直接改变44.1%（15/34）病例的治疗策略，包括开始化疗或靶向抗菌治疗。结论：US-PLB是一种安全、准确、无辐射的儿童周围性肺病变诊断技术，可为临床决策提供重要的组织病理学和微生物学指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular and Interventional Radiology 医学-核医学

CiteScore

4.30

自引率

10.30%

发文量

942

审稿时长

90 days

期刊介绍： JVIR, published continuously since 1990, is an international, monthly peer-reviewed interventional radiology journal. As the official journal of the Society of Interventional Radiology, JVIR is the peer-reviewed journal of choice for interventional radiologists, radiologists, cardiologists, vascular surgeons, neurosurgeons, and other clinicians who seek current and reliable information on every aspect of vascular and interventional radiology. Each issue of JVIR covers critical and cutting-edge medical minimally invasive, clinical, basic research, radiological, pathological, and socioeconomic issues of importance to the field.