Physiology of gastroesophageal reflux in the neonate.

IF 3.2 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Seminars in perinatology Pub Date : 2025-09-04 DOI:10.1016/j.semperi.2025.152130

Alexandra Pottorff, Eric B Ortigoza, Rinarani Sanghavi, Alejandro Llanos-Chea

{"title":"Physiology of gastroesophageal reflux in the neonate.","authors":"Alexandra Pottorff, Eric B Ortigoza, Rinarani Sanghavi, Alejandro Llanos-Chea","doi":"10.1016/j.semperi.2025.152130","DOIUrl":null,"url":null,"abstract":"<p><p>Gastroesophageal reflux is physiologically normal in infants but can become gastroesophageal reflux disease when it leads to significant symptoms (persistent vomiting, weight loss, feeding difficulties). Gastroesophageal reflux disease is highly prevalent among infants and contributes to increased health care utilization. There are several physiologic and lifestyle factors that predispose infants to a higher degree of gastroesophageal reflux and disease related to it. Preterm infants and infants admitted to the neonatal intensive care unit, are a special population that have unique risk factors for gastroesophageal reflux disease and have a high prevalence of gastroesophageal reflux disease. To better understand gastroesophageal reflux in infants and neonates with medical complexity, this article will first review the physiology of typical swallowing and motility of the upper gastrointestinal tract in infants. Then, the pathophysiology of gastroesophageal reflux in infants will be reviewed. Finally, this article also addresses specific physiological differences in preterm infants that are important to aid in the understanding of management of gastroesophageal reflux disease in this specific population.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152130"},"PeriodicalIF":3.2000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.semperi.2025.152130","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Gastroesophageal reflux is physiologically normal in infants but can become gastroesophageal reflux disease when it leads to significant symptoms (persistent vomiting, weight loss, feeding difficulties). Gastroesophageal reflux disease is highly prevalent among infants and contributes to increased health care utilization. There are several physiologic and lifestyle factors that predispose infants to a higher degree of gastroesophageal reflux and disease related to it. Preterm infants and infants admitted to the neonatal intensive care unit, are a special population that have unique risk factors for gastroesophageal reflux disease and have a high prevalence of gastroesophageal reflux disease. To better understand gastroesophageal reflux in infants and neonates with medical complexity, this article will first review the physiology of typical swallowing and motility of the upper gastrointestinal tract in infants. Then, the pathophysiology of gastroesophageal reflux in infants will be reviewed. Finally, this article also addresses specific physiological differences in preterm infants that are important to aid in the understanding of management of gastroesophageal reflux disease in this specific population.

查看原文本刊更多论文

新生儿胃食管反流的生理学研究。

婴儿胃食管反流在生理上是正常的，但当它导致显著症状（持续呕吐、体重减轻、进食困难）时，可成为胃食管反流病。胃食管反流病在婴儿中非常普遍，并有助于增加保健利用。有几个生理和生活方式因素使婴儿易患较高程度的胃食管反流和相关疾病。早产儿和新生儿重症监护病房的婴儿是胃食管反流病的特殊人群，具有独特的危险因素，胃食管反流病的患病率很高。为了更好地了解具有医学复杂性的婴儿和新生儿胃食管反流，本文将首先回顾婴儿典型吞咽和上胃肠道运动的生理学。然后，对婴儿胃食管反流的病理生理进行综述。最后，本文还讨论了早产儿的特定生理差异，这对理解胃食管反流病在这一特定人群中的管理很重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Seminars in perinatology 医学-妇产科学

CiteScore

5.80

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： The purpose of each issue of Seminars in Perinatology is to provide authoritative and comprehensive reviews of a single topic of interest to professionals who care for the mother, the fetus, and the newborn. The journal''s readership includes perinatologists, obstetricians, pediatricians, epidemiologists, students in these fields, and others. Each issue offers a comprehensive review of an individual topic, with emphasis on new developments that will have a direct impact on their practice.