{"title":"A systematic review on volumetric analysis in orbital MRI.","authors":"Michiel Degraeve, Virginie Ninclaus, Julie Deferm, Nele Brusselaers, Reinhilde Jacobs, Robin Willaert","doi":"10.1007/s00234-025-03734-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>Volumetric analysis of orbital soft tissues using magnetic resonance imaging (MRI) offers valuable diagnostic and pathophysiological insights into orbital inflammation, trauma, and tumors. However, the optimal MRI protocols and post-processing methods for specific conditions remain unclear.</p><p><strong>Methods: </strong>A systematic search was performed in PubMed/MEDLINE, Web of Science, and Cochrane Library for all studies published before November 2024. This review adhered to PRISMA guidelines and was prospectively registered. Primary outcomes included (i) MRI acquisition parameters, (ii) post-processing volumetry techniques, and (iii) regions of interest (ROI). Secondary outcomes assessed clinical relevance and validation methods.</p><p><strong>Results: </strong>From 4323 records, 35 articles were included. Significant heterogeneity was observed regarding MRI acquisition and post-processing techniques. Volumetry most commonly targeted extraocular muscles and orbital fat, although definitions of ROI borders varied widely. Analysis of the globe, orbital cavity, optic nerve, and lacrimal gland was less frequent. Validation of volumetric methods was reported in only a minority of studies.</p><p><strong>Conclusions: </strong>Accurate interpretation of volumetric data requires careful consideration of technical variables. Standardization of acquisition protocols, validated segmentation methods, and automated volumetry approaches are essential for enhancing reproducibility and clinical applicability. This systematic review provides a comprehensive framework for future research in orbital MRI volumetry.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2533-2549"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00234-025-03734-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: Volumetric analysis of orbital soft tissues using magnetic resonance imaging (MRI) offers valuable diagnostic and pathophysiological insights into orbital inflammation, trauma, and tumors. However, the optimal MRI protocols and post-processing methods for specific conditions remain unclear.
Methods: A systematic search was performed in PubMed/MEDLINE, Web of Science, and Cochrane Library for all studies published before November 2024. This review adhered to PRISMA guidelines and was prospectively registered. Primary outcomes included (i) MRI acquisition parameters, (ii) post-processing volumetry techniques, and (iii) regions of interest (ROI). Secondary outcomes assessed clinical relevance and validation methods.
Results: From 4323 records, 35 articles were included. Significant heterogeneity was observed regarding MRI acquisition and post-processing techniques. Volumetry most commonly targeted extraocular muscles and orbital fat, although definitions of ROI borders varied widely. Analysis of the globe, orbital cavity, optic nerve, and lacrimal gland was less frequent. Validation of volumetric methods was reported in only a minority of studies.
Conclusions: Accurate interpretation of volumetric data requires careful consideration of technical variables. Standardization of acquisition protocols, validated segmentation methods, and automated volumetry approaches are essential for enhancing reproducibility and clinical applicability. This systematic review provides a comprehensive framework for future research in orbital MRI volumetry.
目的：利用磁共振成像（MRI）对眼眶软组织进行体积分析，为眼眶炎症、创伤和肿瘤的诊断和病理生理学提供有价值的见解。然而，针对特定情况的最佳MRI方案和后处理方法仍不清楚。方法：系统检索PubMed/MEDLINE、Web of Science和Cochrane Library，检索2024年11月之前发表的所有研究。该综述遵循PRISMA指南并进行前瞻性注册。主要结果包括(i) MRI采集参数，（ii）后处理体积测量技术，（iii）感兴趣区域（ROI）。次要结果评估临床相关性和验证方法。结果：共纳入4323篇文献35篇。在MRI采集和后处理技术方面观察到显著的异质性。尽管ROI边界的定义差异很大，但体积测量最常针对眼外肌肉和眶脂肪。对眼球、眶腔、视神经和泪腺的分析较少。只有少数研究报道了体积法的有效性。结论：准确解释体积数据需要仔细考虑技术变量。采集协议的标准化、经过验证的分割方法和自动体积测定方法对于提高可重复性和临床适用性至关重要。本系统综述为未来眼眶MRI体积测量的研究提供了一个全面的框架。
期刊介绍：
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
