{"title":"A Benzothiazole Derived Fluorescent Sensor for Real-time Detection of Aluminums Ion and Application in Real Samples and Living Cells.","authors":"Liangping Li, Guiying Hu, Wen Qin, Zhiqian Liang, Xuerong Yang, Zhiyong Xing","doi":"10.1007/s10895-025-04468-8","DOIUrl":null,"url":null,"abstract":"<p><p>Excessive aluminum ions (Al<sup>3+</sup>) contaminate environmental water bodies, and once they remain in the human body, they will pose a threat to human health. In this paper, a benzothiazole-based fluorescent sensor named BHMH for detecting Al<sup>3+</sup> was successfully synthesized and comprehensively characterized. It exhibited remarkable selectivity and sensitivity, manifested by a substantial fluorescence augmentation and a discernible color alteration in the presence of Al<sup>3+</sup>. The job plot, <sup>1</sup>H NMR titration and HRMS demonstrated that the BHMH and Al<sup>3+</sup> complex exhibited a 1:1 stoichiometric binding affinity. Furthermore, the limit of detection (LOD) for Al<sup>3+</sup> was calculated as 4 × 10<sup>-8</sup> M. Additionally, BHMH demonstrated successful application in the precise detection of Al<sup>3+</sup> across diverse aqueous samples, test papers and cell imaging within living HSC cells.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fluorescence","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10895-025-04468-8","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Excessive aluminum ions (Al3+) contaminate environmental water bodies, and once they remain in the human body, they will pose a threat to human health. In this paper, a benzothiazole-based fluorescent sensor named BHMH for detecting Al3+ was successfully synthesized and comprehensively characterized. It exhibited remarkable selectivity and sensitivity, manifested by a substantial fluorescence augmentation and a discernible color alteration in the presence of Al3+. The job plot, 1H NMR titration and HRMS demonstrated that the BHMH and Al3+ complex exhibited a 1:1 stoichiometric binding affinity. Furthermore, the limit of detection (LOD) for Al3+ was calculated as 4 × 10-8 M. Additionally, BHMH demonstrated successful application in the precise detection of Al3+ across diverse aqueous samples, test papers and cell imaging within living HSC cells.
期刊介绍：
Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.
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