Effectiveness of self-assembling peptide in reducing bleeding after colorectal endoscopic submucosal dissection.

IF 7.5 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastrointestinal endoscopy Pub Date : 2025-09-03 DOI:10.1016/j.gie.2025.08.042

Takeshi Yamamura, Masanao Nakamura, Mio Hiramatsu, Genta Uchida, Keisaku Yamada, Takeshi Kuno, Keiko Maeda, Tsunaki Sawada, Eri Ishikawa, Takashi Hirose, Takuya Ishikawa, Kazuhiro Furukawa, Takashi Honda, Hiroki Kawashima

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引用次数: 0

Abstract

Background and aims: The newly developed self-assembling peptide (SAP) is expected to exert hemostatic effects on the gastrointestinal tract and promote ulcer healing. However, its efficacy in preventing postprocedural hemorrhage after colorectal endoscopic submucosal dissection (ESD) remains uncertain. This study aimed to determine whether SAP could reduce hematochezia, including delayed bleeding (DB), and prevent its occurrence after colorectal ESD.

Methods: This multicenter retrospective study included 1597 patients with 1654 colorectal ESD-related lesions treated between January 2017 and July 2024. Initially, 1419 lesions were analyzed and categorized into non-SAP and SAP groups. Subsequently, the differences between lesions with and without postprocedural hematochezia and DB were explored. Factors associated with hematochezia and DB were examined using univariate and multivariate logistic regression analyses.

Results: A total of 719 and 700 lesions were assigned to the non-SAP and SAP groups, respectively. The use of SAP was associated with a significant reduction in hematochezia. In addition, SAP significantly reduced DB. SAP was identified as a significant factor in the prevention of hematochezia and DB after colorectal ESD.

Conclusions: The application of SAP significantly reduced the occurrence of hematochezia and DB after colorectal ESD. Furthermore, SAP was a significant factor associated with the reduction of hematochezia and DB. Therefore, SAP may be appropriate for the prevention of post-ESD bleeding in the colon.

查看原文本刊更多论文

自组装肽在减少结肠内镜下粘膜下剥离术后出血中的作用。

背景与目的：新开发的自组装肽（SAP）有望对胃肠道发挥止血作用，促进溃疡愈合。然而，其在预防结肠内镜下粘膜下剥离（ESD）术后出血中的作用仍不确定。本研究旨在确定SAP是否可以减少包括延迟出血（DB）在内的便血，并预防结直肠ESD后便血的发生。方法：这项多中心回顾性研究纳入了2017年1月至2024年7月期间治疗的1597例1,654例结直肠esd相关病变患者。最初，分析了1419个病变，并将其分为非SAP组和SAP组。随后，探讨有无术后便血和DB病变的差异。使用单变量和多变量logistic回归分析检查与便血和DB相关的因素。结果：共有719和700个病变被划分为非SAP组和SAP组。SAP的使用与便血的显著减少有关。此外，SAP显著降低了DB。SAP被认为是预防结直肠ESD后便血和DB的重要因素。结论：应用SAP可显著降低结肠ESD术后便血和DB的发生。此外，SAP是减少便血和DB的重要因素。因此，SAP可能适用于预防esd后结肠出血。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastrointestinal endoscopy 医学-胃肠肝病学

CiteScore

10.30

自引率

7.80%

发文量

1441

审稿时长

38 days

期刊介绍： Gastrointestinal Endoscopy is a journal publishing original, peer-reviewed articles on endoscopic procedures for studying, diagnosing, and treating digestive diseases. It covers outcomes research, prospective studies, and controlled trials of new endoscopic instruments and treatment methods. The online features include full-text articles, video and audio clips, and MEDLINE links. The journal serves as an international forum for the latest developments in the specialty, offering challenging reports from authorities worldwide. It also publishes abstracts of significant articles from other clinical publications, accompanied by expert commentaries.