Population pharmacokinetics of a single oral dose of gabapentin identifies rapid plasma clearance in rehabilitated Pacific harbor seal pups (Phoca vitulina richardii).
Tess A Rooney, Heather Knych, Mattison Peters, Jenessa Gjeltema, Cara Field
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引用次数: 0
Abstract
Objective: Determine the pharmacokinetic parameters of a single dose of gabapentin administered orally in healthy weaned Pacific harbor seal (HS) pups (Phoca vitulina richardii).
Methods: In the spring of 2023, rehabilitated HS pups were enrolled in this pharmacokinetic study. Seals were administered 10 mg/kg of gabapentin orally in a fish. A sparse sampling model was employed to collect blood samples from 0.25 to 48 hours after drug administration. Plasma drug concentrations were determined using liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were determined using noncompartmental analysis for sparse data.
Results: 15 HSs were included in this study. The mean peak plasma concentration was 7,669.4 ng/mL, the mean time to peak plasma concentration was 1 hour, the mean area under the concentration-versus-time curve from time 0 to infinity was 23,811.8 h·ng/mL, and the mean terminal half-life was 1.9 hours. No adverse effects were observed in any HSs.
Conclusions: The plasma concentration of gabapentin that confers analgesia is not known in veterinary species. During this study, mean gabapentin concentrations exceeded the concentration estimated to treat neuropathic pain in humans only at 1 hour.
Clinical relevance: Gabapentin was rapidly absorbed and eliminated in HSs, indicating that higher dosages and/or frequent dosing of gabapentin may be needed to maintain targeted plasma concentrations in young HSs. Additional studies to investigate the clinical efficacy of gabapentin in veterinary species are warranted, and clinical discretion should be used when applying these results to patients outside of the specific demographic group studied here.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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