Carrier-free nanoparticles based on natural products trigger dual "synergy and attenuation" for enhanced phototherapy of liver cancer

IF 10.2 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Xiongqin Wang , Kunhui Sun , Junlin Dong , Yanli Ge , Haifan Liu , Xingyue Jin , Xiao Pei , Ping Wang , Jianbing Jiang , Tiejie Wang , Xuelei Hu , Shuguang Yuan , Bing Wang , Xie-an Yu
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Abstract

Carrier-free nanoparticles have attracted significant interest owing to their exceptional drug-loading efficiency, simple preparation, and good biosafety. Inspired by the synergism and attenuation strategy of natural products, carrier-free nanoparticles were constructed from a compatibility perspective, aiming to carry natural products to tumor sites as nanoparticles to achieve precise anti-cancer effects. Herein, the carrier-free nanoparticles based on gambogic acid and glycyrrhizic acid (GG NPs) were successfully formed via self-assembly. The internally generated "synergism and attenuation" GG NPs could enhance the anti-tumor effect, reduce toxicity to normal cells, and exhibit tumor-targeting capabilities. Further, to explore the role of GG NPs in enhancing phototherapy, the photosensitizer ZnPc 2 was self-assembled with GG NPs to form GGZ NPs. In vitro studies demonstrated that the GGZ NPs significantly improved phototherapecutic efficacy. Compared with ZnPc 2, the photothermal conversion efficiency was increased to 80.8%, along with a 1.8-fold increase in tumor growth inhibition, and the singlet oxygen yield of GGZ NPs increased by 2-fold. In vivo experiments demonstrated that GGZ NPs exhibit significant liver-targeting ability and could reduce the liver toxicity induced by gambogic acid, as well as decrease the blood biochemical levels of AST and ALT, achieving externally assisted "synergism and attenuation". Hence, carrier-free nanoparticles based on natural products would bring a new treatment modality to the field of precision liver tumor therapy.

Abstract Image

基于天然产物的无载体纳米颗粒触发双重“协同和衰减”,用于增强肝癌光疗
无载体纳米颗粒由于其独特的载药效率、制备简单和良好的生物安全性而引起了人们的极大兴趣。受天然产物协同和衰减策略的启发,从相容性的角度构建无载体纳米颗粒,旨在将天然产物作为纳米颗粒携带到肿瘤部位,达到精确的抗癌效果。本文通过自组装成功制备了基于甘草酸和藤黄酸的无载体纳米颗粒。内部产生的“增效衰减”的GG NPs可以增强抗肿瘤作用,降低对正常细胞的毒性,并表现出肿瘤靶向能力。此外,为了探索GG NPs在增强光疗中的作用,我们将光敏剂ZnPc 2与GG NPs自组装形成GGZ NPs。体外研究表明GGZ NPs显著提高光疗效果。与ZnPc 2相比,GGZ NPs光热转化效率提高至80.8%,肿瘤生长抑制率提高1.8倍,单线态氧产率提高2倍。体内实验表明,GGZ NPs具有明显的肝脏靶向能力,可降低甘竹酚酸对肝脏的毒性,降低血液中AST和ALT的生化水平,实现外源性的“协同衰减”。因此,基于天然产物的无载体纳米颗粒将为肝脏肿瘤精准治疗领域带来新的治疗方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.30
自引率
4.90%
发文量
303
审稿时长
30 days
期刊介绍: Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).
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