Feasibility and limitations of a postal dosimetry audit system using RPLGD for high-dose-rate brachytherapy

IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL
Hyeok-Jun Gwon , Wonho Lee , Sang-Hyoun Choi , Kum Bae Kim
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Abstract

International recommendations and South Korean regulations emphasize the need for dosimetry audit systems to ensure treatment accuracy in high-dose-rate brachytherapy. In this study, we designed and tested a prototype polycarbonate postal audit phantom to assess its feasibility. Using six GD-302M radiophotoluminescent glass dosimeters. Dose measurements were performed at points A and B based on the treatment planning system (TPS) and PHITS. These were validated in the Korea laboratory accreditation scheme and secondary standard dosimetry laboratory using Co-60 beam. Reproducibility and linearity tests showed stable responses; however, a maximum deviation of 13.5 % was observed between the measured and TPS doses at point A. The PHITS simulations revealed that the TPS overestimated the dose by approximately 10 %, whereas glass dosimeters showed up to 20 % overestimation because of low-energy gamma rays from the Ir-192 source. Additional water phantom measurements demonstrated that the RPLGD can provide reasonably consistent dose readings under water-equivalent conditions. The discrepancies observed in the audit phantom were found to follow a consistent trend and could be assessed using normalization. The combined expanded uncertainties were calculated as 3.1 % and 3.2 % (k = 2) for the source holder models 70010 and 72280, respectively. The audit phantom showed potential for application in nationwide postal audits, pending further validation. To ensure clinical applicability, future work should focus on addressing the energy dependence of the RPLGD and conducting a multi-institutional pilot study.
使用RPLGD进行高剂量率近距离放射治疗的邮政剂量学审核系统的可行性和局限性
国际建议和韩国法规强调需要剂量学审计系统,以确保高剂量率近距离放疗的治疗准确性。在本研究中,我们设计并测试了一个原型聚碳酸酯邮政审计模型,以评估其可行性。采用6台GD-302M放射性光致发光玻璃剂量计。根据治疗计划系统(TPS)和PHITS在A点和B点进行剂量测量。这些在韩国实验室认可计划和二级标准剂量测定实验室使用Co-60光束进行了验证。重复性和线性试验表明反应稳定;然而,在a点的测量剂量和TPS剂量之间观察到的最大偏差为13.5%。PHITS模拟显示,TPS高估了大约10%的剂量,而玻璃剂量计由于来自Ir-192源的低能伽马射线而高估了20%。额外的水模测量表明,RPLGD可以在水当量条件下提供相当一致的剂量读数。审计幻影中观察到的差异遵循一致的趋势,可以使用归一化进行评估。源保持器模型70010和72280的综合扩展不确定性分别计算为3.1%和3.2% (k = 2)。审计模型显示了在全国邮政审计中应用的潜力,有待进一步验证。为了确保临床适用性,未来的工作应侧重于解决RPLGD的能量依赖性,并开展多机构的试点研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Radiation Physics and Chemistry
Radiation Physics and Chemistry 化学-核科学技术
CiteScore
5.60
自引率
17.20%
发文量
574
审稿时长
12 weeks
期刊介绍: Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.
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