Electrospun porous nanofibers for sustained drug delivery: Degradation-controlled release through architectural design

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-09-05 DOI:10.1016/j.colsurfb.2025.115126

Min Lao, Xin Li, Yingjie Wang, Junlang Li, Zhengjie Tian, Jiale Zhang, Shaofeng Yin, Xiaoting Deng

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引用次数: 0

Abstract

Diclofenac sodium (DS), a non-steroidal anti-inflammatory drug used for treating inflammatory pain, has a short elimination half-life, which can lead to fluctuations in blood drug concentration. Therefore, developing sustained-release formulations is necessary to meet clinical needs. Biodegradable polymers exhibit excellent sustained-release properties and good biocompatibility, making them suitable for processing into nanofiber-based drug delivery systems via electrospinning technology. Using electrospinning combined with a non-solvent-induced phase separation mechanism, porous nanofibers with different structures were successfully prepared, including non-porous uniaxial nanofibers, porous coaxial nanofibers, double-layered nanofibers with a porous mesh surface, and porous uniaxial nanofibers. The results demonstrated that drug release is influenced by fiber structure and morphology. Among these, the coaxial porous shell-core structure(NFs 2) achieved long-term release kinetics, confirming a synergistic mechanism combining diffusion and matrix degradation. The prepared samples were analyzed using kinetic modeling and were found to conform to the Ritger-Peppas model. This study investigates the impact of electrospun nanofiber structure and morphology on drug delivery, providing significant theoretical and practical insights for the development of innovative sustained-release formulations.

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用于持续给药的电纺多孔纳米纤维：通过结构设计降解控制释放

双氯芬酸钠（DS）是一种用于治疗炎症性疼痛的非甾体抗炎药，其消除半衰期短，可导致血液药物浓度波动。因此，开发缓释制剂是满足临床需要的必要条件。可生物降解聚合物具有优异的缓释性能和良好的生物相容性，适合通过静电纺丝技术加工成纳米纤维为基础的药物输送系统。利用静电纺丝结合非溶剂诱导相分离机制，成功制备了不同结构的多孔纳米纤维，包括无孔单轴纳米纤维、多孔同轴纳米纤维、具有多孔网状表面的双层纳米纤维和多孔单轴纳米纤维。结果表明，药物释放受纤维结构和形态的影响。其中，同轴多孔壳核结构（NFs 2）实现了长期释放动力学，证实了扩散与基质降解相结合的协同机制。对制备的样品进行动力学建模分析，发现符合Ritger-Peppas模型。本研究探讨了静电纺纳米纤维的结构和形态对药物释放的影响，为创新缓释制剂的开发提供了重要的理论和实践见解。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.