Impact of measles vaccination on disease severity and economic burden among children in northern Vietnam, 2017–2019

IF 2.2 Q3 IMMUNOLOGY

Vaccine: X Pub Date : 2025-09-03 DOI:10.1016/j.jvacx.2025.100714

Hoang Dinh Phi , Tran Ngoc Ca , Pham Mai Oanh , Nguyen Thien Phong , Ong Thinh , Pham Thi Hong Nhung

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Abstract

The measles vaccine has a profound impact, significantly reducing incidence and morbidity. However, challenges in achieving high vaccination coverage have resulted in substantial burdens on child health and financial hardship for households. This study evaluates the protective effects of measles vaccination against severity and mortality in Northern Vietnam from 2017 to 2019 and related economics of vaccination.

We conducted a retrospective analysis of all laboratory-confirmed measles cases admitted to Vietnam National Children Hospital (VNCH), estimating odds ratios between vaccinated and unvaccinated groups while considering disease severity, mortality, and potential confounders. We also analyzed cost - benefit using data from two sources, including VNCH data and National Infectious Disease Surveillance System.

Among 2064 inpatients, vaccinated children exhibited fewer pneumonia complications and shorter hospitalization duration. Vaccination significantly reduced the risk of severity and mortality with an adjusted OR = 0.46 (0.28–0.72). Treatment costs were significantly lower in the vaccinated group compared to the unvaccinated group. Cost – benefit analysis show that vaccination can save for 4.98 USD to 26.20 USD per measle case with prior vaccination.

Vaccination significantly reduces severe disease risk, pneumonia complications, and treatment costs. Expanding vaccination coverage (including children, young mothers and women of childbearing age) and targeted financial support in high-risk areas are essential for improving health outcomes and alleviating economic burdens on families.

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2017-2019年越南北部麻疹疫苗接种对儿童疾病严重程度和经济负担的影响

麻疹疫苗具有深远的影响，可显著降低发病率和发病率。然而，在实现高疫苗接种覆盖率方面的挑战给儿童健康带来了沉重负担，并给家庭带来了经济困难。本研究评估了2017年至2019年越南北部麻疹疫苗接种对严重程度和死亡率的保护作用以及疫苗接种的相关经济学。我们对越南国立儿童医院（VNCH）收治的所有实验室确诊麻疹病例进行了回顾性分析，在考虑疾病严重程度、死亡率和潜在混杂因素的情况下，估计了接种疫苗组和未接种疫苗组之间的优势比。我们还使用两个来源的数据分析了成本效益，包括VNCH数据和国家传染病监测系统。在2064例住院患者中，接种疫苗的儿童肺炎并发症较少，住院时间较短。接种疫苗显著降低了严重程度和死亡率的风险，校正OR = 0.46（0.28-0.72）。与未接种疫苗组相比，接种疫苗组的治疗费用显著降低。成本效益分析表明，事先接种麻疹疫苗可为每例麻疹患者节省4.98 ~ 26.20美元。疫苗接种可显著降低严重疾病风险、肺炎并发症和治疗费用。扩大疫苗接种覆盖面（包括儿童、年轻母亲和育龄妇女）并在高风险地区提供有针对性的财政支持，对于改善健康结果和减轻家庭经济负担至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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