Particulate matter (PM2.5, PM10) exposure and assisted reproductive technology outcomes in fresh cycles: a systematic review and meta-analysis

IF 3.7 2区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Atmospheric Environment Pub Date : 2025-09-01 DOI:10.1016/j.atmosenv.2025.121518

Letizia Li Piani , Giovanna Esposito , Eva Negri , Irene La Vecchia , Vittoria Sterpi , Claudia Santucci , Rossella Bonzi , Carlo La Vecchia , Edgardo Somigliana , Paola Viganò , Fabio Parazzini

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引用次数: 0

Abstract

Several studies have assessed the relationship between exposure to particulate matter with aerodynamic diameters ≤2.5 μm (PM_2.5) and ≤10 μm (PM₁₀) and assisted reproduction technology (ART) success rates, with controversial findings. This review aimed to consolidate the current evidence from fresh ART cycles and explore sources of heterogeneity across studies. The outcomes of interest were biochemical and clinical pregnancy, and live birth. Four exposure timeframes were considered: T0 (within 90 days before starting the stimulation protocol), T1 (from the first day of stimulation protocol to oocyte retrieval), T2 (from oocyte retrieval to embryo transfer), and T3 (from embryo transfer to pregnancy).

Database searches were conducted on PubMed/Medline and Embase up to April 2025, using a combination of MeSH/Emtree and generic terms relating to ART patients and air pollution exposure. Fourteen studies, involving 333,438 cycles, were included in the meta-analysis. The studies were conducted between 2010 and 2024 primarily in China (10/14), while 3 were from the USA and one from Korea. We estimated pooled relative risks (RRs) and the corresponding 95% confidence intervals (CIs) for a 10 μg/m³ increase in PM_2.5 and PM₁₀ for biochemical pregnancy, clinical pregnancy, and live births, using random-effects meta-analytic models.

The pooled RRs for 10 μg/m³ increment in PM_2.5 and PM₁₀ at T0 were respectively 0.97 (95%CI: 0.91–1.04) and 0.98 (95%CI: 0.95–1.02) for biochemical pregnancy; for clinical pregnancy they were respectively 0.98 (95%CI: 0.96–1.01) and 0.99 (95%CI: 0.98–1.00). All other findings were close to unity. Substantial heterogeneity was observed across studies for selected outcomes and exposure periods for both pollutants.

This systematic review found no significant association between PM_2.5 and PM₁₀ exposure and ART outcomes after fresh embryo transfer for any of the four exposure windows.

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新鲜循环中颗粒物（PM2.5, PM10）暴露与辅助生殖技术结果：系统回顾和荟萃分析

一些研究评估了空气动力学直径≤2.5 μm （PM2.5）和≤10 μm （PM10）的颗粒物暴露与辅助生殖技术（ART）成功率之间的关系，结果存在争议。本综述旨在巩固来自新的抗逆转录病毒治疗周期的现有证据，并探索各研究的异质性来源。关注的结局是生化和临床妊娠，以及活产。考虑了四个暴露时间框架：T0（开始刺激方案前90天内），T1（从刺激方案的第一天到取卵），T2（从取卵到胚胎移植）和T3（从胚胎移植到怀孕）。截至2025年4月，在PubMed/Medline和Embase上进行了数据库搜索，使用MeSH/Emtree和与ART患者和空气污染暴露相关的通用术语相结合。荟萃分析纳入了14项研究，涉及333,438个周期。这些研究是在2010年至2024年间进行的，主要在中国（10/14），而3个来自美国，一个来自韩国。我们使用随机效应荟萃分析模型，估计生化妊娠、临床妊娠和活产的PM2.5和PM10浓度增加10 μg/m3时的总相对风险（rr）和相应的95%置信区间（ci）。T0时PM2.5和PM10浓度增加10 μg/m3时，生化妊娠的综合相对危险度分别为0.97 （95%CI: 0.91-1.04）和0.98 (95%CI: 0.95-1.02)；临床妊娠分别为0.98 （95%CI: 0.96 ~ 1.01）和0.99 （95%CI: 0.98 ~ 1.00）。所有其他调查结果几乎一致。在两种污染物的选定结果和暴露时间的研究中观察到实质性的异质性。本系统综述发现，在4个暴露窗口中，PM2.5和PM10暴露与新鲜胚胎移植后ART结果没有显著关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atmospheric Environment 环境科学-环境科学

CiteScore

9.40

自引率

8.00%

发文量

458

审稿时长

53 days

期刊介绍： Atmospheric Environment has an open access mirror journal Atmospheric Environment: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atmospheric Environment is the international journal for scientists in different disciplines related to atmospheric composition and its impacts. The journal publishes scientific articles with atmospheric relevance of emissions and depositions of gaseous and particulate compounds, chemical processes and physical effects in the atmosphere, as well as impacts of the changing atmospheric composition on human health, air quality, climate change, and ecosystems.