Long-Term Outcomes of Dental Implants Following Jaw Resection: A Comparative Analysis of Malignant Tumors and Benign Conditions.

IF 1.7
Taro Mukaibo, Osamu Takahashi, Sho Mitsugi, Yusuke Kondo, Manabu Habu, Chihiro Masaki
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Abstract

Purpose: This study aimed to evaluate and compare the survival rates of dental implants used for functional rehabilitation following jaw resection due to malignant tumors versus other causes, including benign tumors, osteomyelitis, or trauma.

Materials and methods: A retrospective study was conducted on 19 patients who underwent jaw resection and implant placement with bone anchored device for wide edentulous areas at XXX XXX University Hospital between June 2013 and February 2024. Patients were divided into two groups: those with jaw defects due to malignant tumors (T1 group) and those with defects from benign tumors, facial trauma, or osteomyelitis (T2 group). Implant survival was analyzed using Kaplan-Meier curves and log-rank tests, with multivariate analyses via Cox proportional hazards models adjusted for age and various clinical factors.

Results: A total of 64 implants were placed, with 48.4% of defects caused by malignant tumors. The 5-year cumulative survival rate was 69.2% at the patient level and 64.5% at the implant level. A significant difference was observed between groups: the T1 group had a 5-year implant survival rate of 34.1% versus 92.3% in the T2 group (p<0.001). The T1 group was significantly older (67.7 ± 9.4 vs. 47.1 ± 15.3 years) and showed a distinct pattern of late failures between 40 and 50 months. Multivariate analyses showed that malignancy remained associated with implant failure across most models, with varying magnitude based on included factors.

Conclusions: Implants placed after jaw resection for malignant tumors showed significantly lower survival rates than those placed after resection for benign conditions. This difference persisted across most multivariate models, though the magnitude of association considerably varied depending on the examined factors. These findings provide the first direct comparison of implant outcomes based on resection pathology and highlight the complex factors influencing implant survival in post-oncologic reconstruction.

下颌切除术后种植牙的长期疗效:恶性肿瘤和良性情况的比较分析。
目的:本研究旨在评估和比较因恶性肿瘤和其他原因(包括良性肿瘤、骨髓炎或创伤)切除颌骨后用于功能康复的种植体的存活率。材料与方法:回顾性研究2013年6月至2024年2月在XXX XXX大学医院行大面积无牙区骨锚定装置下颌切除种植的19例患者。患者分为两组:恶性肿瘤所致颌骨缺损患者(T1组)和良性肿瘤、面部外伤、骨髓炎所致颌骨缺损患者(T2组)。采用Kaplan-Meier曲线和log-rank检验分析种植体存活,并通过Cox比例风险模型进行多因素分析,调整年龄和各种临床因素。结果:共植入种植体64枚,恶性肿瘤缺损占48.4%。患者5年累积生存率为69.2%,种植体5年累积生存率为64.5%。组间比较差异有统计学意义:T1组种植体5年生存率为34.1%,T2组为92.3%。(结论:颌骨恶性肿瘤切除后放置种植体的生存率明显低于良性肿瘤切除后放置种植体的生存率。这种差异在大多数多变量模型中持续存在,尽管关联的大小根据所检查的因素而有很大差异。这些发现首次提供了基于切除病理的种植体结果的直接比较,并强调了影响肿瘤后重建种植体存活的复杂因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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