One year monitoring of calcium release from an experimental composite containing calcium phosphate particles.

Biomaterial investigations in dentistry Pub Date : 2025-08-28 eCollection Date: 2025-01-01 DOI:10.2340/biid.v12.44586

Handially Vilela, Mariana Nakamura, Roberto Braga

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Abstract

Introduction: Ca²⁺ release from specimens made of a composite containing dicalcium phosphate dihydrate particles (CaHPO₄.2H₂O, dicalcium phosphate dihydrate [DCPD]) was followed during 1 year.

Methods: Specimens were individually immersed in deionized water (n = 3). Every 2 weeks, immersion medium was collected and specimens were transferred to new vials with fresh medium. Ca²⁺ release was quantified using induced coupled plasma-optical emission spectrometry (ICP-OES). Data were analyzed by ANOVA/Tukey test (alpha: 5%).

Results: Ca²⁺ release was observed during the entire 12-month period. Cumulative release was 1635.1 ± 145.3 μg/cm² (179.7 ± 16.0 ppm), corresponding to 23.8 ± 2.0% of the total Ca mass in the specimen.

Conclusion: The tested composite was capable of sustained Ca²⁺ release in water for 1 year. In spite of the limitations of this screening test, the results suggest that composites containing Calcium phosphate (CaP) particles could offer a long-term Ca²⁺ supply to the adjacent dental tissues.

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对含有磷酸钙颗粒的实验性复合材料进行为期一年的钙释放监测。

介绍：用含有二水合磷酸二钙颗粒（CaHPO4.2H2O，二水合磷酸二钙[DCPD]）的复合材料制成的样品中Ca2+的释放情况，随访1年。方法：将标本单独浸泡在去离子水中（n = 3）。每2周收集浸泡培养基，将标本转移到装有新鲜培养基的新瓶中。采用诱导耦合等离子体光学发射光谱法（ICP-OES）定量测定Ca2+释放。数据分析采用方差分析/Tukey检验（alpha: 5%）。结果：在整个12个月期间观察到Ca2+释放。累积释放量为1635.1±145.3 μg/cm2(179.7±16.0 ppm)，相当于样品中Ca总质量的23.8±2.0%。结论：所制备的复合材料能在水中持续释放Ca2+ 1年。尽管该筛选试验存在局限性，但结果表明，含有磷酸钙（CaP）颗粒的复合材料可以为邻近的牙组织提供长期的Ca2+供应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterial investigations in dentistry

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审稿时长

14 weeks