Rufus O Akinyemi, Oladotun V Olalusi, Gabriel O Ogunde, Tolulope O Akinyemi, Joseph O Yaria, Olabode Oguntiloye, Ayotomiwa Fagbemi, Eniola O Cadmus, Femi O Popoola, Mayowa Ogunronbi, Dorcas Olujobi, Olaoluwa Famuyiwa, Joshua O Akinyemi, Mayowa O Owolabi, Roman Romero-Ortuno, Adesola Ogunniyi, Raj Kalaria, Brian Lawlor
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Abstract
Previous evidence suggests there are racial, genetic, and geographic differences in hand grip strength (HGS) underlying the need to define population-specific normative values and their determinants. We determined the normative values of HGS and investigated its correlates in an urban community sample in Nigeria. We assessed 607 participants from the Vascular heAlth, fraiLty, and cognItion in Ageing Nigerians sTudy [VALIANT] - a population-based cohort of 1031 older persons in Ibadan, a city in Southwestern Nigeria. They were recruited through a multi-stage, stratified cluster random sampling method. HGS was defined as the highest recorded/maximum HGS (max. HGS) of both hands. The determinants (β coefficient, p values) of HGS were identified using linear regression model. The mean (SD) age of the participants was 64.6 (11.5) with 67.8 % females. The mean (SD) max. HGS (in kg) of the study population was 19.65±10.16 overall; 24.51(14.01) among males and 17.31(6.51) among females (p < 0.001). Overall, female sex (β=-6.38, p < 0.001), clinical frailty (β=-1.35, p < 0.001), and baseline MoCA scores (β=0.37, p 0.001) were independently associated with max. HGS. In the subgroup analysis, presence of hypertension (β=2.64, p < 0.001) and diabetes mellitus (β=-2.61, p 0.05) were independently associated with max. HGS among females, but not males. Our findings buttress the intricate link between overall physical, cardiometabolic as well as cognitive health in this unique West African population.
先前的证据表明，握力（HGS）存在种族、遗传和地理差异，因此需要定义特定人群的规范值及其决定因素。我们确定了HGS的规范性值，并在尼日利亚的一个城市社区样本中调查了其相关性。我们评估了来自尼日利亚老年人血管健康、虚弱和认知研究[VALIANT]的607名参与者，该研究是在尼日利亚西南部城市伊巴丹进行的以人口为基础的1031名老年人队列研究。他们是通过多阶段分层整群随机抽样方法招募的。HGS被定义为记录的最高/最大HGS (max。HGS)的双手。采用线性回归模型确定HGS的决定因素（β系数，p值）。参与者的平均（SD）年龄为64.6岁（11.5岁），其中67.8%为女性。均值（SD）最大值。研究人群总体HGS（单位kg）为19.65±10.16；男性为24.51(14.01)，女性为17.31(6.51)（p < 0.001）。总体而言，女性性别（β=-6.38, p < 0.001）、临床虚弱（β=-1.35, p < 0.001）和基线MoCA评分（β=0.37, p < 0.001）与max独立相关。硫化汞。在亚组分析中，高血压（β=2.64, p < 0.001）和糖尿病（β=-2.61, p 0.05）与max独立相关。女性中有HGS，但男性中没有。我们的发现支持了这一独特的西非人群整体身体、心脏代谢和认知健康之间的复杂联系。
期刊介绍：
The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons. The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).
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