{"title":"COVID-19: ocular manifestations and associations with corneal transplant rejection and uveitis reactivation.","authors":"Ori Saban, Thuy Doan, Gerami D Seitzman","doi":"10.1097/ICU.0000000000001165","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>To highlight the ocular manifestations associated with COVID-19 and review the evidence surrounding proposed associations with corneal transplant rejection and uveitis reactivation.</p><p><strong>Recent findings: </strong>SARS-CoV-2 has been associated with various ocular manifestations, most commonly conjunctivitis. Less frequently, more severe complications such as uveitis, retinal vascular occlusions, and neuro-ophthalmic syndromes have been reported. These manifestations are theorized to occur secondary to both direct viral invasion as well as secondary systemic inflammation and immune dysregulation. While case reports suggest a possible link between COVID-19 infection and vaccination and corneal graft rejection, large cohort studies and meta-analyses have not confirmed an association. In contrast, retrospective data suggest a slight increase in uveitis recurrence following COVID-19 infection and vaccination in patients with prior uveitis.</p><p><strong>Summary: </strong>Ocular involvement in COVID-19 ranges from mild conjunctivitis to rare, vision-threatening inflammatory and vascular complications. While case reports have suggested temporal links between COVID-19 infection or vaccination and corneal transplant rejection or uveitis reactivation, current evidence does not support an association with graft rejection, and only a slight increase in uveitis recurrence has been observed in certain high-risk populations. With longer follow-up and prospective analyses, a clearer understanding of underlying mechanisms and risk factors may emerge to better guide ophthalmic management during and beyond the pandemic.</p>","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/ICU.0000000000001165","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: To highlight the ocular manifestations associated with COVID-19 and review the evidence surrounding proposed associations with corneal transplant rejection and uveitis reactivation.
Recent findings: SARS-CoV-2 has been associated with various ocular manifestations, most commonly conjunctivitis. Less frequently, more severe complications such as uveitis, retinal vascular occlusions, and neuro-ophthalmic syndromes have been reported. These manifestations are theorized to occur secondary to both direct viral invasion as well as secondary systemic inflammation and immune dysregulation. While case reports suggest a possible link between COVID-19 infection and vaccination and corneal graft rejection, large cohort studies and meta-analyses have not confirmed an association. In contrast, retrospective data suggest a slight increase in uveitis recurrence following COVID-19 infection and vaccination in patients with prior uveitis.
Summary: Ocular involvement in COVID-19 ranges from mild conjunctivitis to rare, vision-threatening inflammatory and vascular complications. While case reports have suggested temporal links between COVID-19 infection or vaccination and corneal transplant rejection or uveitis reactivation, current evidence does not support an association with graft rejection, and only a slight increase in uveitis recurrence has been observed in certain high-risk populations. With longer follow-up and prospective analyses, a clearer understanding of underlying mechanisms and risk factors may emerge to better guide ophthalmic management during and beyond the pandemic.
期刊介绍:
Current Opinion in Ophthalmology is an indispensable resource featuring key up-to-date and important advances in the field from around the world. With renowned guest editors for each section, every bimonthly issue of Current Opinion in Ophthalmology delivers a fresh insight into topics such as glaucoma, refractive surgery and corneal and external disorders. With ten sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, clinicians and other healthcare professionals alike.