Occurrence of Hepatitis E Virus in Human Patients, Food and Animal Products From Slovakia

IF 2.3 2区农林科学 Q3 INFECTIOUS DISEASES

Zoonoses and Public Health Pub Date : 2025-09-04 DOI:10.1111/zph.70012

Alica Pavlova, Bozena Kocikova, Katarina Dudasova, Rene Mandelik, Michaela Urda Dolinska, Zuzana Paralicova, Anna Jackova

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Abstract

Hepatitis E virus (HEV) is the only zoonotic pathogen that causes human viral hepatitis. Foodborne transmission of this virus is one of the most important transmission routes. In this study, performed in various hospitals between 2019 and 2024, we detected the HEV RNA in samples of 66 suspected patients in Eastern Slovakia. In total, 36 patients were found positive. Phylogenetic analysis of selected sequences (n = 26) showed that the majority (n = 22) clustered to genotype HEV-3 group 1. There were only four isolates that clustered to HEV-3 group 2. Statistically significant risk factors associated with viral hepatitis E were gender, age, health status and consumption of animal products. We also analysed suspected food products consumed by patients (n = 10) and animal product samples from stores (n = 218). Only 2 out of 55 (3.6%) pork liver samples from the same butchery shop were found positive for the HEV RNA, clustering to HEV-3 group 2. None of the other animal or food products were found to be positive. This report is the first to utilise genetic typing of the HEV from Slovakia in human patients, food and animal products. However, a direct relationship between human HEV infection and food was not found.

Abstract Image

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斯洛伐克人类患者、食品和动物产品中戊型肝炎病毒的发生。

戊型肝炎病毒（HEV）是引起人类病毒性肝炎的唯一人畜共患病原体。食源性传播是该病毒最重要的传播途径之一。在2019年至2024年期间在多家医院进行的这项研究中，我们在斯洛伐克东部66名疑似患者的样本中检测到了HEV RNA。总共有36名患者被发现呈阳性。所选序列（n = 26）的系统发育分析表明，大多数（n = 22）聚集在HEV-3基因型1组。仅有4株分离株聚集在HEV-3第2组。与病毒性戊型肝炎相关的统计上显著的危险因素是性别、年龄、健康状况和动物产品的消费。我们还分析了患者食用的疑似食品（n = 10）和商店的动物产品样本（n = 218）。来自同一屠宰场的55份猪肝样本中只有2份（3.6%）检测到HEV RNA阳性，聚集在HEV-3组2。其他动物或食品均未发现阳性。本报告首次在人类患者、食品和动物产品中利用斯洛伐克HEV的基因分型。然而，没有发现人类戊肝病毒感染与食物之间的直接关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zoonoses and Public Health 医学-传染病学

CiteScore

5.30

自引率

4.20%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Zoonoses and Public Health brings together veterinary and human health researchers and policy-makers by providing a venue for publishing integrated and global approaches to zoonoses and public health. The Editors will consider papers that focus on timely collaborative and multi-disciplinary research in zoonoses and public health. This journal provides rapid publication of original papers, reviews, and potential discussion papers embracing this collaborative spirit. Papers should advance the scientific knowledge of the sources, transmission, prevention and control of zoonoses and be authored by scientists with expertise in areas such as microbiology, virology, parasitology and epidemiology. Articles that incorporate recent data into new methods, applications, or approaches (e.g. statistical modeling) which enhance public health are strongly encouraged.