Full-Term In Vivo Development of Frozen-Thawed Mammalian Diapausing Embryos.

IF 1.7 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Reproduction in Domestic Animals Pub Date : 2025-09-01 DOI:10.1111/rda.70123

Sergei Amstislavsky, Irina Rozhkova, Tamara Rakhmanova, Varvara Kozeneva, Eugeny Brusentsev

引用次数: 0

Abstract

Embryonic diapause is widespread among mammals. This is the first report of successful post-thaw in vivo development of mammalian embryos cryopreserved at the diapause stage using mouse as a model species. Live offspring were obtained after cryopreservation of murine embryos and their transfer to pseudo-pregnant recipients. The sex ratio at birth was male-skewed, and the offspring were fertile. The results may open new possibilities for applying the Genome Resource Banking concept to diapausing mammalian species.

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哺乳动物冻融滞育胚胎的足月体内发育。

胚胎滞育在哺乳动物中很普遍。这是首次成功地以小鼠为模型物种在哺乳动物滞育期冷冻胚胎解冻后在体内发育的报道。小鼠胚胎冷冻保存后，将其移植到假怀孕受体中获得活的后代。出生时的性别比是男性倾斜的，后代是可生育的。该结果可能为将基因组资源库概念应用于哺乳动物滞育物种开辟新的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproduction in Domestic Animals 农林科学-奶制品与动物科学

CiteScore

3.00

自引率

5.90%

发文量

238

审稿时长

4-8 weeks

期刊介绍： The journal offers comprehensive information concerning physiology, pathology, and biotechnology of reproduction. Topical results are currently published in original papers, reviews, and short communications with particular attention to investigations on practicable techniques. Carefully selected reports, e. g. on embryo transfer and associated biotechnologies, gene transfer, and spermatology provide a link between basic research and clinical application. The journal applies to breeders, veterinarians, and biologists, and is also of interest in human medicine. Interdisciplinary cooperation is documented in the proceedings of the joint annual meetings. Fields of interest: Animal reproduction and biotechnology with special regard to investigations on applied and clinical research.