Exploring the anticancer potential of R. tridentata extracts: a cytotoxicity study against human prostate cancer cell lines (LNCaP and DU145).

IF 3.5 4区医学 Q2 ONCOLOGY

Medical Oncology Pub Date : 2025-09-05 DOI:10.1007/s12032-025-02953-5

Ali Kudamba, Godfrey S Bbosa, Allan Lugaajju, Henry Wabinga, Nixon Niyonzima, Moses Ocan, Ali M Damani, Hussein M Kafeero, Jamilu E Ssenku, Shaban A Okurut, Muniiru Lubowa, Abdul Walusansa, S Sivagami Sivasundaram, Shobana Shampath, Haruna Muwonge

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Abstract

This study investigates the cytotoxic effects of R. tridentata extracts on prostate cancer cells, providing insight into its potential therapeutic benefits and scientific validation for its traditional use in cancer treatment. The cytotoxicity of R. tridentata extracts was evaluated on prostate cancer cell lines (LNCaP and DU 145) using the MTT assay, with doxorubicin as a reference standard. Our findings demonstrated significant concentration- and time-dependent cytotoxic effects of the extracts on both cell lines (p < 0.0024 to p < 0.0002). Notably, the methanol extract exhibited potent cytotoxicity, with IC₅₀ values ranging from 124.07 to 211 μg/mL (DU145) and 100 to 180 μg/ml (LNCaP) over 24-72 h (p < 0.0024 to p < 0.0001), highlighting its therapeutic potential. This study unveils the promising cytotoxic activity of R. tridentata extracts, particularly methanol extracts, against prostate cancer cells, showcasing their concentration- and time-dependent effects. These findings underscore the potential of plant-derived extracts as therapeutic agents for cancer treatment, warranting further research.

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探索三叉藤提取物的抗癌潜力：对人前列腺癌细胞株（LNCaP和DU145）的细胞毒性研究。

本研究探讨了三叉戟提取物对前列腺癌细胞的细胞毒性作用，为其在癌症治疗中的传统应用提供了潜在的治疗效果和科学验证。采用MTT法，以阿霉素为参比标准品，评价三叉藤提取物对LNCaP和du145前列腺癌细胞的细胞毒性。我们的研究结果表明，提取物对两种细胞系的细胞毒性作用具有显著的浓度和时间依赖性（p50值为124.07至211 μg/mL （DU145）和100至180 μg/mL (LNCaP)），持续24-72小时(p

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来源期刊

Medical Oncology 医学-肿瘤学

CiteScore

4.20

自引率

2.90%

发文量

259

审稿时长

1.4 months

期刊介绍： Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.