J Eduardo Melendez, Karla Chavez, Maribel Henao, Cameron DeShazo, Yeabsera Tamire, Jeyantt Srinivas Sankaran, Gabriel Arevalo
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引用次数: 0
Abstract
Objective: Purified collagen matrix containing a broad-spectrum antimicrobial, polyhexamethylene biguanide (PuraPly Antimicrobial (PCMP); Organogenesis Inc., US) has been shown to be an effective adjunct in managing wounds of different aetiologies. The aim of this study was to show the clinical outcomes of PCMP in the management of pressure injuries (PIs) and its implication on healthcare.
Method: This retrospective study included patients managed with PCMP as an adjunct to standard of care procedures, following debridement of stage 3 and stage 4 PIs in the operating room between December 2021-October 2022. Indices from baseline (index surgery) and subsequent visits, including patient demographics, wound presentation and progression were collected and analysed.
Results: A total of nine patients with sacral PIs were identified. Of these, six were stage 4 and three were stage 3. Smoking was prevalent in seven patients and five patients had diabetes and were obese. At baseline, the median wound area was 30cm2 and bioburden was observed in eight wounds. Following either one or two applications of PCMP, the median wound area was reduced to 16cm2 and the incidence of bioburden decreased to one patient.
Conclusion: This case series suggested that PCMP is an effective adjunct in the management of PIs by supporting healing and managing bioburden. Wounds managed with PCMP did not require the surgeon's standard protocol of daily enzymatic wound debridement and this may decrease the workload for hospital staff.
期刊介绍：
Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice.
In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers.
Specifically, JWC publishes:
High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more
The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide
In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments
Clinical case studies providing information on how to deal with complex wounds
Comprehensive literature reviews on current concepts and practice, including cost-effectiveness
Updates on the activities of wound care societies around the world.
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