Development of a novel acaricide, acynonapyr.

IF 1.8 4区 农林科学 Q2 ENTOMOLOGY
Jun Takahashi, Masahiro Kawaguchi, Koichi Hirata, Keiji Koizumi
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引用次数: 0

Abstract

Acynonapyr is a novel acaricide developed by Nippon Soda Co., Ltd. It contains a unique azabicyclic ring and oxyamine structure and represents the first agricultural chemical that targets calcium-activated potassium channels, classified as Group 33 in the IRAC Mode of Action Classification. Acynonapyr exhibits high selectivity against spider mites across all developmental stages and has minimal impact on beneficial insects and natural enemies, rendering it suitable for Integrated Pest Management systems. The compound acts by inhibiting potassium ion flow through KCa2 channels in spider mites, leading to neurological symptoms such as convulsions and impaired mobility and ultimately resulting in mortality. Electrophysiological studies have demonstrated that acynonapyr effectively blocks Tetranychus urticae calcium-activated potassium channels. Importantly, acynonapyr shows little activity against mammalian calcium-activated potassium channels, contributing to its favorable safety profile. The compound shows efficacy against acaricide-resistant spider mite populations, providing a useful tool for pesticide resistance management.

Abstract Image

Abstract Image

Abstract Image

一种新型杀螨剂的研制。
Acynonapyr是日本汽水株式会社开发的一种新型杀螨剂。它含有一个独特的氮杂环和氧胺结构,是第一个针对钙活化钾通道的农业化学品,在IRAC作用模式分类中被归类为第33组。在所有发育阶段,Acynonapyr对蜘蛛螨都有很高的选择性,对益虫和天敌的影响最小,适合用于害虫综合治理系统。该化合物通过抑制蜘蛛螨体内钾离子通过KCa2通道而起作用,导致抽搐和活动能力受损等神经系统症状,最终导致死亡。电生理研究表明,无氰蚜能有效阻断荨麻叶螨钙活化钾通道。重要的是,无氰apyr对哺乳动物钙活化钾通道的活性很小,这有助于其良好的安全性。该化合物对具有抗螨性的蜘蛛螨种群具有一定的杀灭效果,为农药抗性管理提供了有益的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Pesticide Science
Journal of Pesticide Science 农林科学-昆虫学
CiteScore
4.30
自引率
4.20%
发文量
28
审稿时长
18-36 weeks
期刊介绍: The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.
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