{"title":"Cardiovascular challenges of aging in a hotter environment: a narrative review.","authors":"Rachel M Cottle, S Tony Wolf, W Larry Kenney","doi":"10.1152/japplphysiol.00323.2025","DOIUrl":null,"url":null,"abstract":"<p><p>The increase in duration, severity, and frequency of extreme heat will have a profound detrimental impact on human health, as extreme heat is the deadliest weather-related event around the world. At the same time, the population of older (>65 yr) adults is rapidly expanding. The exaggerated heat, coupled with an aging population, increases the number of people at risk during environmental extremes. During heat waves, cardiovascular events and complications secondary to elevated core temperatures are the leading cause of increased morbidity and mortality among older adults. Seminal work demonstrates an impaired cardiovascular response to elevated core and skin temperatures in older adults, resulting in an attenuated capacity to lose heat coupled with increased cardiac strain, in support of the epidemiological data. Here, we review the impact of heat stress on the aged cardiovascular system and highlight the question: \"In what specific environments does an increased cardiovascular strain begin to occur in older adults?\"</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"832-838"},"PeriodicalIF":3.3000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481594/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/japplphysiol.00323.2025","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The increase in duration, severity, and frequency of extreme heat will have a profound detrimental impact on human health, as extreme heat is the deadliest weather-related event around the world. At the same time, the population of older (>65 yr) adults is rapidly expanding. The exaggerated heat, coupled with an aging population, increases the number of people at risk during environmental extremes. During heat waves, cardiovascular events and complications secondary to elevated core temperatures are the leading cause of increased morbidity and mortality among older adults. Seminal work demonstrates an impaired cardiovascular response to elevated core and skin temperatures in older adults, resulting in an attenuated capacity to lose heat coupled with increased cardiac strain, in support of the epidemiological data. Here, we review the impact of heat stress on the aged cardiovascular system and highlight the question: "In what specific environments does an increased cardiovascular strain begin to occur in older adults?"
期刊介绍:
The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.