Uterine Reaction to Oxytocin and Maternal-Neonatal Outcomes in Inducing Labor: A Retrospective Cohort Study.

IF 2.6 4区医学 Q2 OBSTETRICS & GYNECOLOGY

International Journal of Women's Health Pub Date : 2025-08-30 eCollection Date: 2025-01-01 DOI:10.2147/IJWH.S532773

Huahua Liu, Zhanhong Fan, Fan Wu, Mingbo Wang, Ziyi Yang, Feng Zhang

{"title":"Uterine Reaction to Oxytocin and Maternal-Neonatal Outcomes in Inducing Labor: A Retrospective Cohort Study.","authors":"Huahua Liu, Zhanhong Fan, Fan Wu, Mingbo Wang, Ziyi Yang, Feng Zhang","doi":"10.2147/IJWH.S532773","DOIUrl":null,"url":null,"abstract":"Background: Previous studies did not investigate the effect of gradually increasing the concentration of low-dose oxytocin on mother and newborn outcomes. The purpose of this study was to look at the relationship between oxytocin responsiveness and outcomes for both mothers and newborns during labor induction.Methods: This retrospective cohort study was conducted at Nantong Maternal and Child Health Hospital, and participants were divided into the early reaction to oxytocin group and the later reaction to oxytocin group based on oxytocin response. Primary outcomes included Apgar score at 1 and 5 minutes, umbilical cord artery pH, neonatal intensive care unit admission, and postpartum hemorrhage. Secondary outcomes assessed the duration of labor. Multiple regression models were used to compare maternal and infant outcomes between the two groups.Results: A total of 1803 participants were finally included in the statistical analysis, with 1083 in the early reaction to oxytocin group and 720 in the later reaction to oxytocin group. After adjusting for potential confounding factors, the risk of a lower 1-minute Apgar score (OR: 1.924, 95% CI: 1.012-3.655), an increased rate of neonatal intensive care unit admission (OR: 2.064, 95% CI: 1.150-3.703), and a higher incidence of postpartum hemorrhage were observed in the later reaction to oxytocin group (OR: 2.342, 95% CI: 1.631-3.361). Additionally, in this group, the first and second phases of labor were seen to be more drawn out (P<0.001, P<0.001).Conclusion: Later reaction to oxytocin was consistently associated with lower 1-minute Apgar scores, an increased number of admissions to neonatal intensive care units, a labor's first and second phases lasting a long time, and an increased occurrence of postpartum hemorrhage. These findings underscore the importance of identifying women who exhibit a delayed response to oxytocin in clinical practice.Trial registration: The project was retrospectively registered with the Chinese Clinical Trial Registry (TRN: ChiCTR2100047137; 08/06/2021).","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2793-2803"},"PeriodicalIF":2.6000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407008/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Women's Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJWH.S532773","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Previous studies did not investigate the effect of gradually increasing the concentration of low-dose oxytocin on mother and newborn outcomes. The purpose of this study was to look at the relationship between oxytocin responsiveness and outcomes for both mothers and newborns during labor induction.

Methods: This retrospective cohort study was conducted at Nantong Maternal and Child Health Hospital, and participants were divided into the early reaction to oxytocin group and the later reaction to oxytocin group based on oxytocin response. Primary outcomes included Apgar score at 1 and 5 minutes, umbilical cord artery pH, neonatal intensive care unit admission, and postpartum hemorrhage. Secondary outcomes assessed the duration of labor. Multiple regression models were used to compare maternal and infant outcomes between the two groups.

Results: A total of 1803 participants were finally included in the statistical analysis, with 1083 in the early reaction to oxytocin group and 720 in the later reaction to oxytocin group. After adjusting for potential confounding factors, the risk of a lower 1-minute Apgar score (OR: 1.924, 95% CI: 1.012-3.655), an increased rate of neonatal intensive care unit admission (OR: 2.064, 95% CI: 1.150-3.703), and a higher incidence of postpartum hemorrhage were observed in the later reaction to oxytocin group (OR: 2.342, 95% CI: 1.631-3.361). Additionally, in this group, the first and second phases of labor were seen to be more drawn out (P<0.001, P<0.001).

Conclusion: Later reaction to oxytocin was consistently associated with lower 1-minute Apgar scores, an increased number of admissions to neonatal intensive care units, a labor's first and second phases lasting a long time, and an increased occurrence of postpartum hemorrhage. These findings underscore the importance of identifying women who exhibit a delayed response to oxytocin in clinical practice.

Trial registration: The project was retrospectively registered with the Chinese Clinical Trial Registry (TRN: ChiCTR2100047137; 08/06/2021).

Abstract Image

查看原文本刊更多论文

子宫对催产素的反应与引产的母婴结局：一项回顾性队列研究。

背景：以前的研究没有调查逐渐增加低剂量催产素浓度对母亲和新生儿结局的影响。本研究的目的是观察催产素反应与引产过程中母亲和新生儿结局之间的关系。方法：在南通市妇幼保健院进行回顾性队列研究，根据催产素反应分为催产素早期反应组和催产素后期反应组。主要结局包括1分钟和5分钟时的Apgar评分、脐带动脉pH值、新生儿重症监护病房入院情况和产后出血。次要结果评估分娩持续时间。采用多元回归模型比较两组母婴结局。结果：最终纳入统计分析的参与者共1803人，其中早期反应组1083人，后期反应组720人。在调整了潜在的混杂因素后，催产素组1分钟Apgar评分较低（OR: 1.924, 95% CI: 1.012-3.655）、新生儿重症监护病房入院率较高（OR: 2.064, 95% CI: 1.150-3.703）、产后出血发生率较高（OR: 2.342, 95% CI: 1.631-3.361）。此外，在这一组中，第一和第二产程被认为是更长的(结论：较晚的催产素反应始终与较低的1分钟Apgar评分、新生儿重症监护病房入院人数增加、分娩第一和第二阶段持续时间较长以及产后出血的发生率增加有关。这些发现强调了在临床实践中识别对催产素反应延迟的女性的重要性。试验注册：本项目已在中国临床试验注册中心回顾性注册（TRN: ChiCTR2100047137; 08/06/2021）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.