Comparison of Outcomes of Transcatheter Edge-to-Edge Repair With Early Versus Latest Generation MitraClip for Severe Mitral Regurgitation.

IF 2.2 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart, Lung and Circulation Pub Date : 2025-09-03 DOI:10.1016/j.hlc.2025.06.1033

Khin May Thaw, William Scalia, Ronan Petersen, Su Hnin Hlaing, Michael Savage, Dale Murdoch, Karl Poon, O Christopher Raffel, Katherine Lau, Stephen Tomlinson, Lisa Walters, Gregory Scalia, Darren L Walters

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引用次数: 0

Abstract

Background: The fourth-generation MitraClip G4 system is the latest version of the transcatheter edge-to-edge repair (TEER) system for mitral regurgitation (MR).

Aim: This study aimed to evaluate the effectiveness of the MitraClip G4 in the reduction of MR compared to the early-generation MitraClip.

Method: We performed a retrospective analysis of consecutive patients undergoing TEER for MR with either the early-generation or newer-generation MitraClip G4 from a single-centre registry. Baseline patient characteristics and echocardiographic data were compared between groups.

Results: Between December 2011 and February 2024, a total of 183 patients underwent mitral TEER. Of these, 140 patients were treated with early-generation MitraClip, and 43 patients were treated with the G4 system. Reduction of MR to grade≤1 was achieved in 59.5% of patients treated with the G4 MitraClip compared to 25.7% in the early-generation cohort (p<0.001). There was a significant reduction in median MR severity post-TEER in the G4 cohort compared to the early-generation group (p=0.006) (median change: 3 grades in the G4 group). There was no significant difference in post-TEER (moderate or severe) mitral stenosis (p=0.743). No significant difference was noted in the median number of clips used. No significant difference was noted in baseline characteristics, although a proportionally higher number of previous coronary interventions and coronary artery bypass grafts were observed in the early-generation MitraClip group.

Conclusions: The MitraClip G4 system achieved significantly greater reduction of MR severity compared to the earlier generation mitral TEER device.

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早期与最新一代二尖瓣夹经导管边缘对边缘修复治疗严重二尖瓣返流的效果比较。

背景：第四代MitraClip G4系统是用于二尖瓣反流（MR）的经导管边缘到边缘修复（TEER）系统的最新版本。目的：本研究旨在评估MitraClip G4与早期MitraClip相比在降低MR方面的有效性。方法：我们对单中心注册的连续接受TEER的MR患者进行回顾性分析，这些患者使用早期或新一代MitraClip G4。比较两组患者的基线特征和超声心动图数据。结果：2011年12月至2024年2月，共有183例患者接受了二尖瓣TEER。其中，140名患者接受了早期MitraClip治疗，43名患者接受了G4系统治疗。使用G4 MitraClip治疗的患者中，有59.5%的患者实现了MR降至≤1级，而在早期队列中，这一比例为25.7%。（结论：与早期二尖瓣TEER装置相比，MitraClip G4系统实现了更显著的MR严重程度降低。）

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart, Lung and Circulation CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.50

自引率

3.80%

发文量

912

审稿时长

11.9 weeks

期刊介绍： Heart, Lung and Circulation publishes articles integrating clinical and research activities in the fields of basic cardiovascular science, clinical cardiology and cardiac surgery, with a focus on emerging issues in cardiovascular disease. The journal promotes multidisciplinary dialogue between cardiologists, cardiothoracic surgeons, cardio-pulmonary physicians and cardiovascular scientists.