Importance of radiation-related cognitive decline in older adults who receive cranial radiation.

IF 2.8 3区医学 Q2 ONCOLOGY

Expert Review of Anticancer Therapy Pub Date : 2025-09-07 DOI:10.1080/14737140.2025.2555472

Felicia H Lew, Karl Cristie Figuracion, Shannon E Fogh, David P Sheppard, Yolanda D Tseng, Lia M Halasz, Jerome J Graber, Samuel Emerson, Simon S Lo, Sara J Hardy

{"title":"Importance of radiation-related cognitive decline in older adults who receive cranial radiation.","authors":"Felicia H Lew, Karl Cristie Figuracion, Shannon E Fogh, David P Sheppard, Yolanda D Tseng, Lia M Halasz, Jerome J Graber, Samuel Emerson, Simon S Lo, Sara J Hardy","doi":"10.1080/14737140.2025.2555472","DOIUrl":null,"url":null,"abstract":"Introduction: Radiation-related cognitive decline (RRCD), characterized by a decline in cognitive functioning within domains, such as memory and executive function, is a known potential consequence of cranial radiation. Older adults are disproportionately vulnerable to cognitive side effects of radiation (RT), and there can be significant impacts on quality of life and independence. Various mechanisms underlying the development of RRCD have been proposed but have not been specifically evaluated in older adults.Areas covered: In this article, we review the studies that have evaluated cognitive effects of cranial radiation in older adults and discuss the mechanisms and factors that may lead to increased vulnerability of RRCD development in older adults.Expert opinion: The review of the literature is limited by the variety of cognitive outcome measurements used as well as different ages evaluated. However, most studies support increased vulnerability to RRCD in older adults. No studies include geriatric assessment or other measures of biological age. Potential interventions include redefining whether different dose constraints are warranted in the older adult population, evaluating new medication interventions and utilizing radiation techniques that treat smaller volumes. Further research is needed to determine whether there is a corresponding reduction in RRCD.","PeriodicalId":12099,"journal":{"name":"Expert Review of Anticancer Therapy","volume":" ","pages":"1-15"},"PeriodicalIF":2.8000,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Anticancer Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14737140.2025.2555472","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Radiation-related cognitive decline (RRCD), characterized by a decline in cognitive functioning within domains, such as memory and executive function, is a known potential consequence of cranial radiation. Older adults are disproportionately vulnerable to cognitive side effects of radiation (RT), and there can be significant impacts on quality of life and independence. Various mechanisms underlying the development of RRCD have been proposed but have not been specifically evaluated in older adults.

Areas covered: In this article, we review the studies that have evaluated cognitive effects of cranial radiation in older adults and discuss the mechanisms and factors that may lead to increased vulnerability of RRCD development in older adults.

Expert opinion: The review of the literature is limited by the variety of cognitive outcome measurements used as well as different ages evaluated. However, most studies support increased vulnerability to RRCD in older adults. No studies include geriatric assessment or other measures of biological age. Potential interventions include redefining whether different dose constraints are warranted in the older adult population, evaluating new medication interventions and utilizing radiation techniques that treat smaller volumes. Further research is needed to determine whether there is a corresponding reduction in RRCD.

查看原文本刊更多论文

接受颅辐射的老年人与辐射相关的认知能力下降的重要性。

导语：辐射相关认知衰退（RRCD）是已知的颅脑辐射的潜在后果，其特征是记忆和执行功能等领域的认知功能下降。老年人尤其容易受到辐射（RT）的认知副作用的影响，并可能对生活质量和独立性产生重大影响。已经提出了RRCD发展的各种机制，但尚未在老年人中进行具体评估。涵盖领域：在本文中，我们回顾了颅辐射对老年人认知影响的研究，并讨论了可能导致老年人RRCD易感性增加的机制和因素。专家意见：文献综述受到使用的认知结果测量的多样性以及评估的不同年龄的限制。然而，大多数研究支持老年人对RRCD的易感性增加。没有研究包括老年评估或其他生物年龄的测量。潜在的干预措施包括重新定义在老年人群中是否需要不同的剂量限制，评估新的药物干预措施，以及利用治疗较小体积的辐射技术。需要进一步的研究来确定RRCD是否有相应的减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.