Targeted metabolomics reveals dysregulated tryptophan metabolism in retinitis pigmentosa

IF 2.7 2区医学 Q1 OPHTHALMOLOGY

Experimental eye research Pub Date : 2025-09-03 DOI:10.1016/j.exer.2025.110624

Yijie Yang, Xue Han, Jiawei Shen, Zhaoqi Zhu, Peirong Lu

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Abstract

Retinitis pigmentosa (RP) is an inherited retinal degenerative disease characterized by progressive retinal pigment epithelium dysfunction and photoreceptor apoptosis, yet its pathogenesis remains unclear and no cure exists. Emerging evidence implicates the role of tryptophan metabolism in neuroinflammatory processes, prompting our investigation of serum tryptophan metabolites in RP patients versus healthy controls. Through targeted metabolomic profiling and clinical characterization, including age of onset, best corrected visual acuity (BCVA) and retinal thickness, we identified significant alterations in RP patients: marked decreases in cinnabarinic acid, xanthurenic acid, quinolinic acid and indole-3-carboxaldehyde (all p < 0.01), alongside elevated 5-Hydroxyindole-3-acetic acid (5-HIAA, p < 0.001). These disturbances correlated strongly with retinal thickness changes and were more pronounced in late-onset RP compared to early-onset. Our findings reveal tryptophan metabolic dysregulation as a potential feature of RP progression, providing both potential biomarkers and therapeutic targets for RP.

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靶向代谢组学揭示色素性视网膜炎中色氨酸代谢失调。

色素性视网膜炎（RP）是一种以进行性视网膜色素上皮功能障碍和光感受器凋亡为特征的遗传性视网膜退行性疾病，其发病机制尚不清楚，目前尚无治愈方法。新出现的证据暗示了色氨酸代谢在神经炎症过程中的作用，促使我们对RP患者与健康对照组的血清色氨酸代谢物进行研究。通过有针对性的代谢组学分析和临床特征，包括发病年龄、最佳矫正视力（BCVA）和视网膜厚度，我们发现了RP患者的显著变化：朱砂酸、黄嘌呤酸、喹啉酸和吲哚-3-甲醛(均为p

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来源期刊

Experimental eye research 医学-眼科学

CiteScore

6.80

自引率

5.90%

发文量

323

审稿时长

66 days

期刊介绍： The primary goal of Experimental Eye Research is to publish original research papers on all aspects of experimental biology of the eye and ocular tissues that seek to define the mechanisms of normal function and/or disease. Studies of ocular tissues that encompass the disciplines of cell biology, developmental biology, genetics, molecular biology, physiology, biochemistry, biophysics, immunology or microbiology are most welcomed. Manuscripts that are purely clinical or in a surgical area of ophthalmology are not appropriate for submission to Experimental Eye Research and if received will be returned without review.