Association between maternal circulating total triiodothyronine and subsequent risk of preeclampsia.

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-09-04 DOI:10.1186/s40001-025-03118-w

Jiang-Nan Wu, Faustino R Pérez-López, Ignacio Rodríguez, Li Yao, Lu-Yi Mao

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Abstract

Introduction: To clarify the uncertain association between maternal total triiodothyronine (TT3) levels and preeclampsia risk.

Methods: In a hospital-based cohort of pregnant women with universal thyroid testing, we assessed the association between TT3 and preeclampsia using directed acyclic graphs (DAG) to control confounders.

Results: Maternal TT3 levels were associated with preeclampsia risk, with an adjusted odd ratio (OR) of 2.32 (95% confidence interval (CI) 2.02-2.68) in women with the highest TT3 quartile comparing to those in the lowest quartile. A J-shaped association was identified for early onset preeclampsia, with particularly strong association when thyroid-stimulating hormone exceeded 2.5 μIU/mL (OR, 17.22, 95% CI 4.52-65.60). Gestational age > 18 weeks at measurement significantly modified the effect of TT3 on preeclampsia risk, with an interaction OR of 3.22 (95% CI 1.56-6.62).

Conclusion: Increased maternal TT3 levels were associated with preeclampsia. TT3 may contribute to preeclampsia pathogenesis and serve as a clinical biomarker, especially for early onset cases with thyroid dysfunction.

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母体循环总三碘甲状腺原氨酸与子痫前期风险的关系

前言：阐明母体总三碘甲状腺原氨酸（TT3）水平与子痫前期风险之间的不确定关联。方法：在一个以医院为基础的孕妇普遍甲状腺检测队列中，我们使用有向无环图（DAG）来控制混杂因素，评估TT3和子痫前期之间的关系。结果：母体TT3水平与子痫前期风险相关，TT3水平最高的四分位数女性与TT3水平最低的四分位数女性的调整奇数比（OR）为2.32（95%可信区间（CI） 2.02-2.68）。早发性子痫前期存在j型相关性，当促甲状腺激素超过2.5 μIU/mL时相关性特别强（OR, 17.22, 95% CI 4.52-65.60）。测量时的胎龄bb0 - 18周显著改变了TT3对子痫前期风险的影响，相互作用OR为3.22 （95% CI 1.56-6.62）。结论：母体TT3水平升高与子痫前期有关。TT3可能参与子痫前期的发病机制，并可作为临床生物标志物，特别是对早期发病的甲状腺功能障碍患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.